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PMID: 12196665 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

CSF tau protein phosphorylated at threonine 231 correlates with cognitive decline in MCI subjects.

Neurology ·Vol. 59 ·No. 4 ·2002-08-27 ·Pages 627-9

Buerger K, Teipel SJ, Zinkowski R, Blennow K, Arai H, Engel R, Hofmann-Kiefer K, McCulloch C, Ptok U, Heun R, Andreasen N, DeBernardis J, Kerkman D, Moeller H, Davies P, Hampel H

Abstract

In this longitudinal study of 77 patients with mild cognitive impairment (MCI), the authors analyzed whether levels of tau protein phosphorylated at threonine 231 (p-tau(231)) in CSF correlate with progression of cognitive decline. High CSF p-tau(231) levels at baseline, but not total tau protein levels, correlated with cognitive decline and conversion from MCI to AD. Independently, old age and APOE-epsilon 4 carrier status were predictive as well. Our data indicate that an increased p-tau(231) level is a potential risk factor for cognitive decline in patients with MCI.

MeSH Terms

Adult Age Factors Aged Aged, 80 and over Alzheimer Disease/cerebrospinal fluid,complications,diagnosis Apolipoprotein E4 Apolipoproteins E/genetics Biomarkers/cerebrospinal fluid Cognition Disorders/cerebrospinal fluid,complications,diagnosis,genetics Disease Progression Female Follow-Up Studies Humans Longitudinal Studies Male Middle Aged Neuropsychological Tests Phosphorylation Predictive Value of Tests Regression Analysis Risk Factors Threonine/metabolism tau Proteins/cerebrospinal fluid,metabolism

Chemicals

Apolipoprotein E4 Apolipoproteins E Biomarkers tau Proteins Threonine

Authors & Affiliations

16 authors, click to expand affiliations / ORCID

Buerger K

Dementia Research Section and Memory Clinic, Alzheimer Memorial Center, Department of Psychiatry, Ludwig-Maximilian University, Munich, Germany. katharina.buerger@psy.med.uni-muenchen.de

Teipel S J

Zinkowski R

Blennow K

Arai H

Engel R

Hofmann-Kiefer K

McCulloch C

Ptok U

Heun R

Andreasen N

DeBernardis J

Kerkman D

Moeller H- J

Davies P

Hampel H

Article Info

Journal

Neurology

Abbr.

Neurology

ISSN

0028-3878

DOI

10.1212/wnl.59.4.627

katharina.buerger@psy.med.uni-muenchen.de

Published

2002-08-27

Pages

627-9

Language

English

Region

United States

NLM ID

0401060

Subset

Corrections

ErratumIn

External Links

PubMed source DOI: 10.1212/wnl.59.4.627 View journal details

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CSF tau protein phosphorylated at threonine 231 correlates with cognitive decline in MCI subjects.

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