Trisomy 4q32 leads to 4qter due to a maternal 4/21 translocation.

Journal of medical genetics ·Vol. 12 ·No. 4 ·1975-12-00 ·Pages 425-7

Baccichetti C, Tenconi R, Anglani F, Zacchello F

Abstract

The case is described of a malformed girl with partial trisomy for a segment of the long arm of chromsome (4q32 leads to qter) due to an unfavourable segregation of a maternal reciprocal translocation t(4;21) (q32q22). The clinical comparison between the child and patients previously described by other authors does not suggest the existence of a syndrome associated with trisomy 4q+.

MeSH Terms

Adult Child Chromosome Aberrations Female Humans Male Pedigree Translocation, Genetic Trisomy

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

Baccichetti C

Tenconi R

Anglani F

Zacchello F

References (8)

8 references, click to expand

[Staining of human chromosomes with acridine orange after treatment with 5 bromodeoxyuridine].
C R Acad Sci Hebd Seances Acad Sci D. 1973 Jun 13;276(24):3179-81 PMID: 4125131
[Inherited translocation t(4q minus;18q plus) with unbalanced progeny of different types (author's transl)].
Humangenetik. 1974 Mar 28;21(4):315-21 PMID: 4135065
Translocation, t(4qminus;13qplus), in three generations resulting in partial trisomy of the long arm of chromosome 4 in the fourth generation.
J Med Genet. 1974 Jun;11(2):201-5 PMID: 4135220
Quinacrine mustard fluorescence of human chromosomes: characterization of unusual translocations.
Am J Hum Genet. 1972 Mar;24(2):189-213 PMID: 5016511
[A new technic of analysis of the human karyotype].
C R Acad Sci Hebd Seances Acad Sci D. 1971 May 17;272(20):2638-40 PMID: 4104656
Segregating reciprocal (4;21) (q21;q21) translocation with proposita trisomic for parts of 4q and 21.
J Med Genet. 1973 Dec;10(4):384-9 PMID: 4129974
Partial trisomy 4 resulting from a 4-18 reciprocal translocation.
Ann Genet. 1972 Sep;15(3):191-4 PMID: 4539769
Chromosome preparations of leukocytes cultured from human peripheral blood.
Exp Cell Res. 1960 Sep;20:613-6 PMID: 13772379

Article Info

Journal

Journal of medical genetics

Abbr.

J Med Genet

ISSN

0022-2593

DOI

10.1136/jmg.12.4.425

Published

1975-12-00

Pages

425-7

Language

English

Region

England

NLM ID

2985087R

PMCID

PMC1013328

Subset

External Links

PubMed source DOI: 10.1136/jmg.12.4.425 PMC Full Text View journal details

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Trisomy 4q32 leads to 4qter due to a maternal 4/21 translocation.

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