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PMID: 12183596 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Yersinia high-pathogenicity island contributes to virulence in Escherichia coli causing extraintestinal infections.

Infection and immunity ·Vol. 70 ·No. 9 ·2002-09-00 ·Pages 5335-7

Schubert S, Picard B, Gouriou S, Heesemann J, Denamur E

Abstract

The Yersinia high-pathogenicity island (HPI) encodes an iron uptake system mediated by the siderophore yersiniabactin (Ybt) and confers the virulence of highly pathogenic Yersinia species. This HPI is also widely distributed in human pathogenic members of the family of Enterobacteriaceae, above all in extraintestinal pathogenic Escherichia coli (ExPEC). In the present study we demonstrate a highly significant correlation of a functional HPI and extraintestinal virulence in E. coli. Moreover, using a mouse infection model, we show for the first time that the HPI contributes to the virulence of ExPEC.

MeSH Terms
Animals Escherichia coli/genetics,metabolism,pathogenicity Escherichia coli Infections/etiology,microbiology Genes, Bacterial Humans Iron/metabolism Mice Phenols Siderophores/genetics,metabolism Thiazoles Virulence/genetics Yersinia/genetics,metabolism,pathogenicity
Chemicals
Phenols Siderophores Thiazoles yersiniabactin Iron
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Schubert Sören
Max von Pettenkofer-Institut für Hygiene und Medizinische Mikrobiologie, 80336 Munich, Germany. schubert@pk-i.med.uni-muenchen.de
Picard Bertrand
Gouriou Stéphanie
Heesemann Jürgen
Denamur Erick
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16 references, click to expand
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Article Info
Journal
Infection and immunity
Abbr.
Infect Immun
ISSN
0019-9567
DOI
10.1128/IAI.70.9.5335-5337.2002
Email
schubert@pk-i.med.uni-muenchen.de
Published
2002-09-00
Pages
5335-7
Language
English
Region
United States
NLM ID
0246127
PMCID
PMC128248
Subset
IM
External Links
PubMed source DOI: 10.1128/IAI.70.9.5335-5337.2002 PMC Full Text View journal details
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