| GeneLibs

题目:: Cancer-homing toxins.
作者:: Ng(H C),Khoo(H E)
状态:: 发布时间2002-08-12 , 更新时间 2012-11-15
期刊:: Curr Pharm Des
摘要:: Cancer-homing toxins are a group of man-made cytotoxic molecules targeting cancer cells. In the past decade they have demonstrated potential as cancer therapeutics. These molecules contain a toxin, natural or usually derivatized, connected to a cancer-homing module, such as a monoclonal antibody or growth factor or their derivatives. Various cancer-homing toxins have been designed and tested in cell-lines, animal-models and clinical trials. We review some of these data and discuss ways to better design cancer-homing toxins in the light of advances in cancer genomics, antibody-engineering techniques and computational algorithms.
语言:: eng
DOI:

文献库文献相关信息