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PMID: 12163465 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S. Review

The cell biology of Listeria monocytogenes infection: the intersection of bacterial pathogenesis and cell-mediated immunity.

The Journal of cell biology ·Vol. 158 ·No. 3 ·2002-08-05 ·Pages 409-14

Portnoy DA, Auerbuch V, Glomski IJ

Abstract

Listeria monocytogenes has emerged as a remarkably tractable pathogen to dissect basic aspects of cell biology, intracellular pathogenesis, and innate and acquired immunity. In order to maintain its intracellular lifestyle, L. monocytogenes has evolved a number of mechanisms to exploit host processes to grow and spread cell to cell without damaging the host cell. The pore-forming protein listeriolysin O mediates escape from host vacuoles and utilizes multiple fail-safe mechanisms to avoid causing toxicity to infected cells. Once in the cytosol, the L. monocytogenes ActA protein recruits host cell Arp2/3 complexes and enabled/vasodilator-stimulated phosphoprotein family members to mediate efficient actin-based motility, thereby propelling the bacteria into neighboring cells. Alteration in any of these processes dramatically reduces the ability of the bacteria to establish a productive infection in vivo.

MeSH Terms
Actins/immunology,metabolism,ultrastructure Animals Bacterial Toxins Cell Movement/immunology Eukaryotic Cells/metabolism,microbiology,ultrastructure Heat-Shock Proteins/immunology,metabolism Hemolysin Proteins Host-Parasite Interactions/physiology Humans Immunity, Cellular/physiology Listeria monocytogenes/metabolism,pathogenicity,ultrastructure Listeriosis/metabolism,physiopathology Models, Biological
Chemicals
Actins Bacterial Toxins Heat-Shock Proteins Hemolysin Proteins hlyA protein, Listeria monocytogenes
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Portnoy Daniel A
Department of Molecular and Cell Biology, University of California, Berkeley 94720, USA. portnoy@uclink4.berkeley.edu
Auerbuch Victoria
Glomski Ian J
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Article Info
Journal
The Journal of cell biology
Abbr.
J Cell Biol
ISSN
0021-9525
DOI
10.1083/jcb.200205009
Email
portnoy@uclink4.berkeley.edu
Published
2002-08-05
Epub
2002-00-05
Pages
409-14
Language
English
Region
United States
NLM ID
0375356
PMCID
PMC2173830
Subset
IM
Grants
NIAID NIH HHS · R01 AI027655 · United States
NIAID NIH HHS · R37 AI029619 · United States
NIAID NIH HHS · AI27655 · United States
NIAID NIH HHS · AI29619 · United States
External Links
PubMed source DOI: 10.1083/jcb.200205009 PMC Full Text View journal details
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