Home LiteratureArticle Details
PMID: 12160087 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S. Review

Timing of exposure and mammary cancer risk.

Journal of mammary gland biology and neoplasia ·Vol. 7 ·No. 1 ·2002-01-00 ·Pages 67-76

Lamartiniere CA

Abstract

We have tested the hypothesis that timing of exposure to hormonally active chemicals can predetermine susceptibility for mammary cancer. TCDD, the most potent man-made xenobiotic, when given to pregnant rats resulted in the offspring being more susceptible to chemically induced mammary cancer as adults. On the other hand, genistein, the primary isoflavone component of soy, given in the diet during the prepubertal period, or the prepubertal and adult periods, protected against chemically induced mammary cancer. There was an inverse relationship between cancer susceptibility and mammary gland differentiation. The initial effect of early exposure to genistein was to up-regulate the EGF-signaling pathway and to enhance cell differentiation, resulting in reduced EGF-receptor expression in mammary terminal end buds of adults. Genistein has been shown to be bioavailable to the mammary gland in postnatal rats. Differentiation effects are believed to occur via an imprinting mechanism that determines the "blueprint" from which the mammary cells respond to future hormonal and/or xenobiotic exposure.

MeSH Terms
Animals Anticarcinogenic Agents/therapeutic use Biological Availability Carcinogens/toxicity ErbB Receptors/metabolism Female Genistein/therapeutic use Humans Mammary Neoplasms, Experimental/chemically induced,metabolism,prevention & control Rats Risk Factors Time Factors Up-Regulation
Chemicals
Anticarcinogenic Agents Carcinogens Genistein ErbB Receptors
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Lamartiniere Coral A
Department of Pharmacology and Toxicology, University of Alabama at Birmingham, 35294, USA. coral.lamartiniere@ccc.uab.edu
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Article Info
Journal
Journal of mammary gland biology and neoplasia
Abbr.
J Mammary Gland Biol Neoplasia
ISSN
1083-3021
DOI
10.1023/a:1015722507237
Email
coral.lamartiniere@ccc.uab.edu
Published
2002-01-00
Pages
67-76
Language
English
Region
United States
NLM ID
9601804
Subset
IM
Grants
NCI NIH HHS · R01-CA61742 · United States
NIEHS NIH HHS · R01-ES07273 · United States
External Links
PubMed source DOI: 10.1023/a:1015722507237 View journal details
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