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PMID: 12160085 Published · ppublish English Journal Article Review

Hormonal control of alveolar development and its implications for breast carcinogenesis.

Journal of mammary gland biology and neoplasia ·Vol. 7 ·No. 1 ·2002-01-00 ·Pages 39-48

Brisken C

Abstract

During puberty and pregnancy, the breast undergoes major restructuring in order to produce a structure that can secrete and eject copious amounts of milk. By analogy to other branched organs such as the lung or the salivary gland, a large increase in surface area of the specialized epithelium is achieved through repeated ramifications of a system of ducts and alveoli arising from the nipple. In the breast, this process culminates in the appearance of thousands of alveoli or acini, saccular outpouchings from the ductal system. This paper focuses on this final stage of proliferation, the formation of alveolar structures and its control by systemic hormones.

MeSH Terms
Animals Breast/growth & development Breast Neoplasms/pathology Cell Division/physiology Cell Transformation, Neoplastic/pathology Epithelial Cells/cytology,metabolism Female Gonadal Steroid Hormones/physiology Growth Hormone/physiology Humans Mammary Glands, Animal/growth & development Mammary Neoplasms, Animal/pathology Mice Morphogenesis/physiology Pregnancy
Chemicals
Gonadal Steroid Hormones Growth Hormone
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Brisken Cathrin
Surgical Oncology, MGH Cancer Center, Harvard Medical School, Boston, Massachusetts 02114, USA. Cathrin.Brisken@isrec.unil.ch
References (49)
49 references, click to expand
  1. Stat5a is mandatory for adult mammary gland development and lactogenesis.
    Genes Dev. 1997 Jan 15;11(2):179-86 PMID: 9009201
  2. Breast cancer (1)
    N Engl J Med. 1992 Jul 30;327(5):319-28 PMID: 1620171
  3. Cell proliferation in normal human breast ducts, fibroadenomas, and other ductal hyperplasias measured by nuclear labeling with tritiated thymidine. Effects of menstrual phase, age, and oral contraceptive hormones.
    Hum Pathol. 1977 Jan;8(1):67-81 PMID: 844855
  4. Prevention of the polycystic ovarian phenotype and characterization of ovulatory capacity in the estrogen receptor-alpha knockout mouse.
    Endocrinology. 1999 Dec;140(12):5855-65 PMID: 10579351
  5. A mammalian model for Laron syndrome produced by targeted disruption of the mouse growth hormone receptor/binding protein gene (the Laron mouse).
    Proc Natl Acad Sci U S A. 1997 Nov 25;94(24):13215-20 PMID: 9371826
  6. SOCS1 deficiency results in accelerated mammary gland development and rescues lactation in prolactin receptor-deficient mice.
    Genes Dev. 2001 Jul 1;15(13):1631-6 PMID: 11445538
  7. Relationship between previous reproductive history and chemically induced mammary cancer in rats.
    Int J Cancer. 1969 May 15;4(3):312-7 PMID: 5801418
  8. Null mutation of the prolactin receptor gene produces multiple reproductive defects in the mouse.
    Genes Dev. 1997 Jan 15;11(2):167-78 PMID: 9009200
  9. Progesterone receptors in the mouse mammary duct: distribution and developmental regulation.
    Cell Growth Differ. 1996 Jul;7(7):945-52 PMID: 8809412
  10. C/EBPbeta (CCAAT/enhancer binding protein) controls cell fate determination during mammary gland development.
    Mol Endocrinol. 2000 Mar;14(3):359-68 PMID: 10707954
  11. Pattern of distribution of cells positive for estrogen receptor alpha and progesterone receptor in relation to proliferating cells in the mammary gland.
    Breast Cancer Res Treat. 1999 Feb;53(3):217-27 PMID: 10369068
  12. Estrogen receptors alpha and beta in the rodent mammary gland.
    Proc Natl Acad Sci U S A. 2000 Jan 4;97(1):337-42 PMID: 10618419
  13. Role of estrogen receptor-alpha in the anterior pituitary gland.
    Mol Endocrinol. 1997 Jun;11(6):674-81 PMID: 9171231
  14. Prolactin controls mammary gland development via direct and indirect mechanisms.
    Dev Biol. 1999 Jun 1;210(1):96-106 PMID: 10364430
  15. Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation.
    Cell. 1998 Apr 17;93(2):165-76 PMID: 9568710
  16. Short-term exposure to estrogen and progesterone induces partial protection against N-nitroso-N-methylurea-induced mammary tumorigenesis in Wistar--Furth rats.
    Cancer Lett. 2001 Aug 10;169(1):1-6 PMID: 11410318
  17. Cellular turnover in the mammary gland is correlated with systemic levels of progesterone and not 17beta-estradiol during the estrous cycle.
    Biol Reprod. 2001 Sep;65(3):680-8 PMID: 11514328
  18. Endocrine control of mammarygland development and function in the C3H/ He Crgl mouse.
    J Natl Cancer Inst. 1958 Dec;21(6):1039-63 PMID: 13611531
  19. Targeted disruption of the glucocorticoid receptor gene blocks adrenergic chromaffin cell development and severely retards lung maturation.
    Genes Dev. 1995 Jul 1;9(13):1608-21 PMID: 7628695
  20. The osteoclast differentiation factor osteoprotegerin-ligand is essential for mammary gland development.
    Cell. 2000 Sep 29;103(1):41-50 PMID: 11051546
  21. Impact of progesterone receptor on cell-fate decisions during mammary gland development.
    Proc Natl Acad Sci U S A. 2000 Mar 28;97(7):3044-9 PMID: 10737785
  22. Differential expression of the growth hormone receptor and growth hormone-binding protein in epithelia and stroma of the mouse mammary gland at various physiological stages.
    J Endocrinol. 1999 Apr;161(1):77-87 PMID: 10194531
  23. The mRNA encoding a parathyroid hormone-like peptide is produced in mammary tissue in response to elevations in serum prolactin.
    Mol Endocrinol. 1989 Sep;3(9):1443-7 PMID: 2608067
  24. Effect of oestradiol on progesterone receptors in normal mammary glands and its relationship with lactation.
    Biochem J. 1979 Jul 15;182(1):127-31 PMID: 496902
  25. A paracrine role for the epithelial progesterone receptor in mammary gland development.
    Proc Natl Acad Sci U S A. 1998 Apr 28;95(9):5076-81 PMID: 9560231
  26. Mice lacking progesterone receptor exhibit pleiotropic reproductive abnormalities.
    Genes Dev. 1995 Sep 15;9(18):2266-78 PMID: 7557380
  27. Transgenic mice carrying an imbalance in the native ratio of A to B forms of progesterone receptor exhibit developmental abnormalities in mammary glands.
    Proc Natl Acad Sci U S A. 1998 Jan 20;95(2):696-701 PMID: 9435255
  28. Parathyroid hormone-related protein: a developmental regulatory molecule necessary for mammary gland development.
    J Mammary Gland Biol Neoplasia. 1999 Jan;4(1):21-34 PMID: 10219904
  29. The chicken progesterone receptor A and B isoforms are products of an alternate translation initiation event.
    J Biol Chem. 1989 Aug 25;264(24):14062-4 PMID: 2760059
  30. Fibroblast growth factor receptor signalling has a role in lobuloalveolar development of the mammary gland.
    J Cell Sci. 1997 Jun;110 ( Pt 11):1261-8 PMID: 9202386
  31. Prolactin (PRL) and its receptor: actions, signal transduction pathways and phenotypes observed in PRL receptor knockout mice.
    Endocr Rev. 1998 Jun;19(3):225-68 PMID: 9626554
  32. Evidence that the mammary fat pad mediates the action of growth hormone in mammary gland development.
    Endocrinology. 1998 Feb;139(2):659-62 PMID: 9449638
  33. Prolactin, growth hormone, and epidermal growth factor activate Stat5 in different compartments of mammary tissue and exert different and overlapping developmental effects.
    Dev Biol. 2001 Jan 1;229(1):163-75 PMID: 11133161
  34. The regulation of the prolactin receptor gene expression in the mammary gland of early pregnant mouse.
    Endocr J. 1997 Feb;44(1):53-8 PMID: 9152614
  35. Rescue of preimplantatory egg development and embryo implantation in prolactin receptor-deficient mice after progesterone administration.
    Endocrinology. 2000 Jul;141(7):2691-7 PMID: 10875275
  36. Dissociation between steroid receptor expression and cell proliferation in the human breast.
    Cancer Res. 1997 Nov 15;57(22):4987-91 PMID: 9371488
  37. Induction of mammary gland development in estrogen receptor-alpha knockout mice.
    Endocrinology. 2000 Aug;141(8):2982-94 PMID: 10919287
  38. Immunocytochemical localization of estrogen receptors alpha and beta in the human reproductive organs.
    J Clin Endocrinol Metab. 2000 Dec;85(12):4835-40 PMID: 11134151
  39. Elucidation of a role for stromal steroid hormone receptors in mammary gland growth and development using tissue recombinants.
    J Mammary Gland Biol Neoplasia. 1997 Oct;2(4):393-402 PMID: 10935027
  40. Hormonal synergism in mammary growth.
    Proc R Soc Lond B Biol Sci. 1958 Dec 17;149(936):303-25 PMID: 13623785
  41. On the origin and progression of ductal carcinoma in the human breast.
    J Natl Cancer Inst. 1973 May;50(5):1111-8 PMID: 4123242
  42. Mammary gland development is mediated by both stromal and epithelial progesterone receptors.
    Mol Endocrinol. 1997 Jun;11(6):801-11 PMID: 9171243
  43. Defective mammopoiesis, but normal hematopoiesis, in mice with a targeted disruption of the prolactin gene.
    EMBO J. 1997 Dec 1;16(23):6926-35 PMID: 9384572
  44. Estrogen receptor beta is coexpressed with ERalpha and PR and associated with nodal status, grade, and proliferation rate in breast cancer.
    Am J Pathol. 2000 Jan;156(1):29-35 PMID: 10623650
  45. Subgroup of reproductive functions of progesterone mediated by progesterone receptor-B isoform.
    Science. 2000 Sep 8;289(5485):1751-4 PMID: 10976068
  46. Effects of castration and chronic steroid treatments on hypothalamic gonadotropin-releasing hormone content and pituitary gonadotropins in male wild-type and estrogen receptor-alpha knockout mice.
    Endocrinology. 1998 Oct;139(10):4092-101 PMID: 9751487
  47. Ectopic pituitary grafts in mice: hormone levels, effects on fertility, and the development of adenomyosis uteri, prolactinomas, and mammary carcinomas.
    Endocrinology. 1985 Apr;116(4):1440-8 PMID: 3971922
  48. Alteration of reproductive function but not prenatal sexual development after insertional disruption of the mouse estrogen receptor gene.
    Proc Natl Acad Sci U S A. 1993 Dec 1;90(23):11162-6 PMID: 8248223
  49. Generation and reproductive phenotypes of mice lacking estrogen receptor beta.
    Proc Natl Acad Sci U S A. 1998 Dec 22;95(26):15677-82 PMID: 9861029
Article Info
Journal
Journal of mammary gland biology and neoplasia
Abbr.
J Mammary Gland Biol Neoplasia
ISSN
1083-3021
DOI
10.1023/a:1015718406329
Email
cathrin.brisken@isrec.unil.ch
Published
2002-01-00
Pages
39-48
Language
English
Region
United States
NLM ID
9601804
Subset
IM
External Links
PubMed source DOI: 10.1023/a:1015718406329 View journal details
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