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PMID: 12150821 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S. Review

RNA interference: the new somatic cell genetics?

Cancer cell ·Vol. 2 ·No. 1 ·2002-07-00 ·Pages 17-23

Paddison PJ, Hannon GJ

Abstract

RNAi is evolving into a powerful tool for manipulating gene expression in mammalian cells with potential utility for investigating gene function, for high-throughput, function-based genetic screens and potentially for development as a therapeutic tool.

MeSH Terms

Animals Base Sequence Cells, Cultured Cytogenetic Analysis DNA-Directed RNA Polymerases/metabolism Gene Expression Gene Silencing Humans Models, Genetic RNA, Double-Stranded/chemistry,genetics RNA, Small Interfering/chemical synthesis,genetics,metabolism Viral Proteins

Chemicals

RNA, Double-Stranded RNA, Small Interfering Viral Proteins bacteriophage T7 RNA polymerase DNA-Directed RNA Polymerases

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Paddison Patrick J

Cold Spring Harbor Laboratory, Watson School of Biological Sciences, 1 Bungtown Road, Cold Spring Harbor, New York 11724, USA.

Hannon Gregory J

Article Info

Journal

Cancer cell

Abbr.

Cancer Cell

ISSN

1535-6108

DOI

10.1016/s1535-6108(02)00092-2

Published

2002-07-00

Pages

17-23

Language

English

Region

United States

NLM ID

101130617

Subset

Grants

NCI NIH HHS · P01-CA13106 · United States

NIGMS NIH HHS · R01-GM62534 · United States

External Links

PubMed source DOI: 10.1016/s1535-6108(02)00092-2 View journal details

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RNA interference: the new somatic cell genetics?

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