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PMID: 12141823 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Plasma leptin and TNF-alpha levels in chronic hepatitis C patients and their relationship to hepatic fibrosis.

Digestive diseases and sciences ·Vol. 47 ·No. 7 ·2002-07-00 ·Pages 1604-10

Crespo J, Rivero M, Fábrega E, Cayón A, Amado JA, García-Unzeta MT, Pons-Romero F

Abstract

The aim of this study was to examine the possible relationship between the plasma levels of leptin and tumor necrosis factor (TNF)-alpha and the stage of hepatic fibrosis in a cohort of patients with chronic hepatitis C. Leptin and TNF levels were measured by RIA in 135 patients and in 75 age- and sex-matched controls. Liver disease was evaluated by the stage of fibrosis and the extent of inflammatory infiltrate in the liver biopsy. Leptin levels correlated with BMI values in healthy controls and in patients with chronic hepatitis C (men, r = 0.61, P = 0.0001; women, r = 0.68, P = 0.003). Leptin levels increased as hepatic fibrosis stage progressed both in male and in female patients (P < 0.001); also, TNF levels were higher in patients with an advanced stage of fibrosis (P = 0.006). In these patients, levels of leptin increased according to the progression of the stage of fibrosis; these data suggest that leptin may play a role in the regulation of hepatic fibrosis.

MeSH Terms
Adult Aged Disease Progression Female Hepatitis C, Chronic/blood Humans Leptin/blood Liver Cirrhosis/blood Male Middle Aged
Chemicals
Leptin
Authors & Affiliations
7 authors, click to expand affiliations / ORCID
Crespo Javier
Gastroenterology and Hepatology Unit, University Hospital Marqués de Valdecilla, University of Cantabria, Santander, Spain.
Rivero Montserrat
Fábrega Emilio
Cayón Amalía
Amado José Antonio
García-Unzeta Maria Teresa
Pons-Romero Fernando
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Article Info
Journal
Digestive diseases and sciences
Abbr.
Dig Dis Sci
ISSN
0163-2116
DOI
10.1023/a:1015835606718
Published
2002-07-00
Pages
1604-10
Language
English
Region
United States
NLM ID
7902782
Subset
IM
External Links
PubMed source DOI: 10.1023/a:1015835606718 View journal details
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