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PMID: 12127939 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Extremely low frequency (ELF) pulsed-gradient magnetic fields inhibit malignant tumour growth at different biological levels.

Cell biology international ·Vol. 26 ·No. 7 ·2002-00-00 ·Pages 599-603

Zhang X, Zhang H, Zheng C, Li C, Zhang X, Xiong W

Abstract

Extremely low frequency (ELF) pulsed-gradient magnetic field (with the maximum intensity of 0.6-2.0 T, gradient of 10-100 T.M(-1), pulse width of 20-200 ms and frequency of 0.16-1.34 Hz treatment of mice can inhibit murine malignant tumour growth, as seen from analyses at different hierarchical levels, from organism, organ, to tissue, and down to cell and macromolecules. Such magnetic fields induce apoptosis of cancer cells, and arrest neoangiogenesis, preventing a supply developing to the tumour. The growth of sarcomas might be amenable to such new method of treatment.

MeSH Terms
Animals Apoptosis/physiology,radiation effects Cell Nucleus/pathology,radiation effects,ultrastructure Electric Stimulation Therapy/methods Electromagnetic Fields Endoplasmic Reticulum, Rough/pathology,radiation effects,ultrastructure Endothelium, Vascular/pathology,radiation effects,ultrastructure Magnetics/therapeutic use Mice Mice, Inbred Strains Microscopy, Electron, Transmission Mitochondria/pathology,radiation effects,ultrastructure Sarcoma, Experimental/pathology,therapy,ultrastructure Soft Tissue Neoplasms/pathology,therapy,ultrastructure
Authors & Affiliations
6 authors, click to expand affiliations / ORCID
Zhang Xinchen
Biomedical Physics Unit, Department of Physics, Wuhan University, Wuhan, 430072, China.
Zhang Husheng
Zheng Congyi
Li Chaoyang
Zhang Xinsong
Xiong Wei
Article Info
Journal
Cell biology international
Abbr.
Cell Biol Int
ISSN
1065-6995
Published
2002-00-00
Pages
599-603
Language
English
Region
England
NLM ID
9307129
Subset
IM
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