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PMID: 12127765 Published · ppublish English Journal Article Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S.

Distinguishing the ORFs from the ELFs: short bacterial genes and the annotation of genomes.

Trends in genetics : TIG ·Vol. 18 ·No. 7 ·2002-07-00 ·Pages 335-7

Ochman H

Abstract

A substantial fraction of hypothetical open reading frames (ORFs) in completely sequenced bacterial genomes are short, suggesting that many are not genes but random stretches of DNA. Although it is not feasible to authenticate the coding capacity of all such regions experimentally, comparisons of ORFs in related genomes can expose those that encode functional proteins.

MeSH Terms
Bacteria/genetics Cloning, Molecular/methods Genome, Bacterial Open Reading Frames Sequence Alignment/methods
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Ochman Howard
Dept of Biochemistry and Molecular Biophysics, 233 Life Sciences South, University of Arizona, Tucson, AZ 85721, USA. hochman@email.arizona.edu
Article Info
Journal
Trends in genetics : TIG
Abbr.
Trends Genet
ISSN
0168-9525
DOI
10.1016/s0168-9525(02)02668-9
Email
hochman@email.arizona.edu
Published
2002-07-00
Pages
335-7
Language
English
Region
England
NLM ID
8507085
Subset
IM
Corrections
CommentIn
PMID: 12615005
External Links
PubMed source DOI: 10.1016/s0168-9525(02)02668-9 View journal details
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