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题目:: Identification of genes differentially expressed between gastric cancers and normal gastric mucosa with cDNA microarrays.
作者:: Lee(Seongeun),Baek(Myungin),Yang(Hankwang),Bang(Yung-Jue),Kim(Woo Ho),Ha(Ji-Hong),Kim(Dae-Kee),Jeoung(Doo-Il)
状态:: 发布时间2002-07-19 , 更新时间 2007-11-15
期刊:: Cancer Lett
摘要:: To identify genes whose alterations lead to gastric cancer, gene expression profiles have been obtained from 22 gastric cancer tissues and their surrounding gastric mucosa tissues. A total of 16 genes were differentially expressed in more than 50% of gastric cancer tissues compared with surrounding gastric mucosa tissues. Genes such as HMG-Y, fibroblast collagenase inhibitor, and osteopontin are among those that are overexpressed in over 50% of the gastric cancer tissues. Dihydrodiol dehydrogenase, ribonuclease A, and glutathione peroxidase are among those genes that are underexpressed in over 50% of the gastric cancer tissues. We identified genes that are associated with clinical phenotypes of patients with gastric cancers. Alpha-II spectrin, Na/K-ATPase and KIAA0111 are those that are enhanced in intestinal type of gastric cancer. Gene such as platelet-endothelial tetraspan antigen 3 was enhanced in highly metastatic gastric cancer tissues.
语言:: eng
DOI:

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