Inhibition of mutant FLT3 receptors in leukemia cells by the small molecule tyrosine kinase inhibitor PKC412.

Animals Antineoplastic Agents/pharmacology Apoptosis/drug effects Benzamides Bone Marrow Cells/enzymology,pathology Bone Marrow Transplantation Cell Cycle/drug effects Cell Division/drug effects Cell Transformation, Neoplastic Drug Resistance, Neoplasm Enzyme Inhibitors/pharmacology Flow Cytometry Humans Imatinib Mesylate Immunoblotting Interleukin-3/metabolism Leukemia, Myeloid, Acute/genetics,pathology,therapy Male Mice Mice, Inbred BALB C Mice, Nude Mutation Phosphorylation Piperazines Protein Kinase C/antagonists & inhibitors Proto-Oncogene Proteins/antagonists & inhibitors Pyrimidines/pharmacology Receptor Protein-Tyrosine Kinases/antagonists & inhibitors Staurosporine/analogs & derivatives,pharmacology Transfection Tumor Cells, Cultured/drug effects fms-Like Tyrosine Kinase 3

Antineoplastic Agents Benzamides Enzyme Inhibitors Interleukin-3 Piperazines Proto-Oncogene Proteins Pyrimidines Imatinib Mesylate FLT3 protein, human Flt3 protein, mouse Receptor Protein-Tyrosine Kinases fms-Like Tyrosine Kinase 3 Protein Kinase C Staurosporine midostaurin