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PMID: 12118257 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Hormonally regulated alpha(4)beta(2)delta GABA(A) receptors are a target for alcohol.

Nature neuroscience ·Vol. 5 ·No. 8 ·2002-08-00 ·Pages 721-2

Sundstrom-Poromaa I, Smith DH, Gong QH, Sabado TN, Li X, Light A, Wiedmann M, Williams K, Smith SS

Abstract

Here we report that low concentrations of alcohol (1-3 mM) increased Cl(-) currents gated by a recombinant GABA(A) receptor, alpha(4)beta(2)delta, by 40-50% in Xenopus laevis oocytes. We also found greater hippocampal expression of receptors containing alpha(4) and delta subunits, using a rat model of premenstrual syndrome (PMS) in which 1-3 mM alcohol preferentially enhanced GABA-gated currents, and low doses of alcohol attenuated anxiety and behavioral reactivity. The alcohol sensitivity of delta-containing receptors may underlie the reinforcing effects of alcohol during PMS, when eye saccade responses to low doses of alcohol are increased.

MeSH Terms
Animals Chlorides/metabolism Disease Models, Animal Dose-Response Relationship, Drug Ethanol/pharmacology Female Hippocampus/metabolism In Vitro Techniques Ion Channel Gating/drug effects Oocytes/drug effects,metabolism Patch-Clamp Techniques Premenstrual Syndrome/chemically induced,metabolism Progesterone/pharmacology Protein Subunits RNA, Messenger/metabolism Rats Receptors, GABA-A/drug effects,genetics,metabolism Recombinant Proteins/drug effects,genetics,metabolism Transfection Xenopus laevis gamma-Aminobutyric Acid/pharmacology
Chemicals
Chlorides Protein Subunits RNA, Messenger Receptors, GABA-A Recombinant Proteins Ethanol Progesterone gamma-Aminobutyric Acid
Authors & Affiliations
9 authors, click to expand affiliations / ORCID
Sundstrom-Poromaa Inger
Department of Physiology and Pharmacology, SUNY Downstate Medical Center, 450 Clarkson Ave., Brooklyn, New York 11203, USA.
Smith Deborah H
Gong Qi Hua
Sabado Thomas N
Li Xinshe
Light Adam
Wiedmann Martin
Williams Keith
Smith Sheryl S
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Article Info
Journal
Nature neuroscience
Abbr.
Nat Neurosci
ISSN
1097-6256
DOI
10.1038/nn888
Published
2002-08-00
Pages
721-2
Language
English
Region
United States
NLM ID
9809671
PMCID
PMC2887346
Subset
IM
Grants
NIDA NIH HHS · DA09618 · United States
NIDA NIH HHS · R01 DA009618-04 · United States
NIDA NIH HHS · R01 DA009618 · United States
NINDS NIH HHS · R01 NS035047 · United States
NIAAA NIH HHS · R01 AA012958-01 · United States
NIAAA NIH HHS · AA12958 · United States
NINDS NIH HHS · NS35047 · United States
NIAAA NIH HHS · R01 AA012958-02 · United States
NIAAA NIH HHS · R01 AA012958 · United States
NIDA NIH HHS · R01 DA009618-05A2 · United States
External Links
PubMed source DOI: 10.1038/nn888 PMC Full Text View journal details
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