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PMID: 12110136 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Review

The role of human T-lymphocyte-monocyte contact in inflammation and tissue destruction.

Arthritis research ·Vol. 4 Suppl 3 ·2002-00-00 ·Pages S169-76

Burger D, Dayer JM

Abstract

Contact-mediated signaling of monocytes by human stimulated T lymphocytes (TL) is a potent proinflammatory mechanism that triggers massive upregulation of the proinflammatory cytokines IL-1 and tumor necrosis factor-alpha. These two cytokines play an important part in chronic destructive diseases, including rheumatoid arthritis. To date this cell-cell contact appears to be a major endogenous mechanism to display such an activity in monocyte-macrophages. Since TL and monocyte-macrophages play a pivotal part in the pathogenesis of chronic inflammatory diseases, we investigated the possible ligands and counter-ligands involved in this cell-cell interaction. We also characterized an inhibitory molecule interfering in this process, apolipoprotein A-I. This review aims to summarize the state of the art and importance of contact-mediated monocyte activation by stimulated TL in cytokine production in rheumatoid arthritis and mechanisms that might control it.

MeSH Terms
Arthritis, Rheumatoid/immunology,pathology Cell Communication/immunology Humans Monocytes/cytology,immunology T-Lymphocytes/cytology,immunology
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Burger Danielle
Division of Immunology and Allergy, Clinical Immunology Unit, University Hospital, Geneva, Switzerland. danielle.burger@hcuge.ch
Dayer Jean-Michel
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Article Info
Journal
Arthritis research
Abbr.
Arthritis Res
ISSN
1465-9905
DOI
10.1186/ar558
Email
danielle.burger@hcuge.ch
Published
2002-00-00
Epub
2002-00-09
Pages
S169-76
Language
English
Region
England
NLM ID
100913255
PMCID
PMC3240134
Subset
IM
External Links
PubMed source DOI: 10.1186/ar558 PMC Full Text
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