Home LiteratureArticle Details
PMID: 12093880 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S. Review

The therapeutic potential of modulating the ceramide/sphingomyelin pathway.

The Journal of clinical investigation ·Vol. 110 ·No. 1 ·2002-07-00 ·Pages 3-8

Kolesnick R

Abstract

暂无摘要

MeSH Terms
Amidohydrolases/metabolism Angioplasty, Balloon, Coronary Animals Apoptosis/physiology Biophysical Phenomena Biophysics Ceramidases Ceramides/chemistry,metabolism Coronary Artery Disease/drug therapy,therapy Coronary Restenosis/prevention & control Humans Models, Biological Neoplasms/drug therapy Oxidoreductases/metabolism Second Messenger Systems Signal Transduction Sphingomyelin Phosphodiesterase/metabolism Sphingomyelins/chemistry,metabolism Transferases (Other Substituted Phosphate Groups)/metabolism
Chemicals
Ceramides Sphingomyelins Oxidoreductases dihydroceramide desaturase Transferases (Other Substituted Phosphate Groups) phosphatidylcholine-ceramide phosphocholine transferase Sphingomyelin Phosphodiesterase Amidohydrolases Ceramidases
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Kolesnick Richard
Laboratory of Signal Transduction, Sloan-Kettering Institute, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA. r-kolesnick@ski.mskcc.org
References (61)
61 references, click to expand
  1. The 1999 Moyer award. Burn injury induces skeletal muscle apoptosis and the activation of caspase pathways in rats.
    J Burn Care Rehabil. 1999 Nov-Dec;20(6):462-70 PMID: 10613683
  2. Cathepsin D targeted by acid sphingomyelinase-derived ceramide.
    EMBO J. 1999 Oct 1;18(19):5252-63 PMID: 10508159
  3. Fas preassociation required for apoptosis signaling and dominant inhibition by pathogenic mutations.
    Science. 2000 Jun 30;288(5475):2354-7 PMID: 10875918
  4. Molecular cloning and characterization of a human mitochondrial ceramidase.
    J Biol Chem. 2000 Jul 14;275(28):21508-13 PMID: 10781606
  5. Molecular cloning and functional characterization of a novel mammalian sphingosine kinase type 2 isoform.
    J Biol Chem. 2000 Jun 30;275(26):19513-20 PMID: 10751414
  6. Compartmentalization of ceramide signaling: physical foundations and biological effects.
    J Cell Physiol. 2000 Sep;184(3):285-300 PMID: 10911359
  7. Ceramide-coated balloon catheters limit neointimal hyperplasia after stretch injury in carotid arteries.
    Circ Res. 2000 Aug 18;87(4):282-8 PMID: 10948061
  8. Combined cytotoxic action of paclitaxel and ceramide against the human Tu138 head and neck squamous carcinoma cell line.
    Cancer Chemother Pharmacol. 2000;46(2):85-92 PMID: 10972477
  9. Oocyte apoptosis is suppressed by disruption of the acid sphingomyelinase gene or by sphingosine-1-phosphate therapy.
    Nat Med. 2000 Oct;6(10):1109-14 PMID: 11017141
  10. How cells handle cholesterol.
    Science. 2000 Dec 1;290(5497):1721-6 PMID: 11099405
  11. Synergistic cytotoxicity in solid tumor cell lines between N-(4-hydroxyphenyl)retinamide and modulators of ceramide metabolism.
    J Natl Cancer Inst. 2000 Dec 6;92(23):1897-909 PMID: 11106681
  12. Ceramide binds to the CaLB domain of cytosolic phospholipase A2 and facilitates its membrane docking and arachidonic acid release.
    FASEB J. 2001 Jan;15(1):7-9 PMID: 11099485
  13. Kinase suppressor of ras is necessary for tumor necrosis factor alpha activation of extracellular signal-regulated kinase/mitogen-activated protein kinase in intestinal epithelial cells.
    Cancer Res. 2001 Feb 1;61(3):963-9 PMID: 11221891
  14. Induction of apoptotic cell death and prevention of tumor growth by ceramide analogues in metastatic human colon cancer.
    Cancer Res. 2001 Feb 1;61(3):1233-40 PMID: 11221856
  15. FTY720 alters lymphocyte homing and protects allografts without inducing general immunosuppression.
    Transplant Proc. 2001 Feb-Mar;33(1-2):530-1 PMID: 11266942
  16. Enzymes of sphingolipid metabolism: from modular to integrative signaling.
    Biochemistry. 2001 Apr 24;40(16):4893-903 PMID: 11305904
  17. KSR: a MAPK scaffold of the Ras pathway?
    J Cell Sci. 2001 May;114(Pt 9):1609-12 PMID: 11309192
  18. Inhibitory actions of ceramide upon PKC-epsilon/ERK interactions.
    Am J Physiol Cell Physiol. 2001 Jun;280(6):C1403-11 PMID: 11350735
  19. Changes in the lipid turnover, composition, and organization, as sphingolipid-enriched membrane domains, in rat cerebellar granule cells developing in vitro.
    J Biol Chem. 2001 Jun 15;276(24):21136-45 PMID: 11264283
  20. Molecular mechanisms of ceramide-mediated CD95 clustering.
    Biochem Biophys Res Commun. 2001 Jun 22;284(4):1016-30 PMID: 11409897
  21. N-(4-hydroxyphenyl)retinamide elevates ceramide in neuroblastoma cell lines by coordinate activation of serine palmitoyltransferase and ceramide synthase.
    Cancer Res. 2001 Jul 1;61(13):5102-5 PMID: 11431347
  22. Endothelial apoptosis as the primary lesion initiating intestinal radiation damage in mice.
    Science. 2001 Jul 13;293(5528):293-7 PMID: 11452123
  23. Lysophospholipids--receptor revelations.
    Science. 2001 Nov 30;294(5548):1875-8 PMID: 11729304
  24. The antitumor ether lipid ET-18-OCH(3) induces apoptosis through translocation and capping of Fas/CD95 into membrane rafts in human leukemic cells.
    Blood. 2001 Dec 15;98(13):3860-3 PMID: 11739199
  25. Molecular ordering of the initial signaling events of CD95.
    Mol Cell Biol. 2002 Jan;22(1):207-20 PMID: 11739735
  26. Ceramide-rich membrane rafts mediate CD40 clustering.
    J Immunol. 2002 Jan 1;168(1):298-307 PMID: 11751974
  27. Solution structure and functional analysis of the cysteine-rich C1 domain of kinase suppressor of Ras (KSR).
    J Mol Biol. 2002 Jan 18;315(3):435-46 PMID: 11786023
  28. Insertional mutagenesis of the mouse acid ceramidase gene leads to early embryonic lethality in homozygotes and progressive lipid storage disease in heterozygotes.
    Genomics. 2002 Feb;79(2):218-24 PMID: 11829492
  29. An essential role for membrane rafts in the initiation of Fas/CD95-triggered cell death in mouse thymocytes.
    EMBO Rep. 2002 Feb;3(2):190-6 PMID: 11818332
  30. De novo ceramide regulates the alternative splicing of caspase 9 and Bcl-x in A549 lung adenocarcinoma cells. Dependence on protein phosphatase-1.
    J Biol Chem. 2002 Apr 12;277(15):12587-95 PMID: 11801602
  31. Alteration of lymphocyte trafficking by sphingosine-1-phosphate receptor agonists.
    Science. 2002 Apr 12;296(5566):346-9 PMID: 11923495
  32. Importance of C1B domain for lipid messenger-induced targeting of protein kinase C.
    J Biol Chem. 2002 May 17;277(20):18037-45 PMID: 11877428
  33. 1,2-Diacylglycerols but not phorbol esters stimulate sphingomyelin hydrolysis in GH3 pituitary cells.
    J Biol Chem. 1987 Dec 15;262(35):16759-62 PMID: 3479432
  34. 1,2-Diacylglycerols, but not phorbol esters, activate a potential inhibitory pathway for protein kinase C in GH3 pituitary cells. Evidence for involvement of a sphingomyelinase.
    J Biol Chem. 1988 May 15;263(14):6534-7 PMID: 2834381
  35. Sphingomyelinase action inhibits phorbol ester-induced differentiation of human promyelocytic leukemic (HL-60) cells.
    J Biol Chem. 1989 May 5;264(13):7617-23 PMID: 2540198
  36. Sphingomyelin turnover induced by vitamin D3 in HL-60 cells. Role in cell differentiation.
    J Biol Chem. 1989 Nov 15;264(32):19076-80 PMID: 2808413
  37. Role of ceramide as a lipid mediator of 1 alpha,25-dihydroxyvitamin D3-induced HL-60 cell differentiation.
    J Biol Chem. 1990 Sep 15;265(26):15823-31 PMID: 2394750
  38. A comprehensive study of the radiobiological response of the murine (BDF1) small intestine.
    Int J Radiat Biol. 1990 Dec;58(6):925-73 PMID: 1978853
  39. Sphingomyelin and derivatives as cellular signals.
    Prog Lipid Res. 1991;30(1):1-38 PMID: 1771169
  40. Sphingosine-1-phosphate as second messenger in cell proliferation induced by PDGF and FCS mitogens.
    Nature. 1993 Oct 7;365(6446):557-60 PMID: 8413613
  41. Identification of arachidonic acid as a mediator of sphingomyelin hydrolysis in response to tumor necrosis factor alpha.
    J Biol Chem. 1994 Feb 25;269(8):5757-63 PMID: 8119915
  42. PKC zeta is a molecular switch in signal transduction of TNF-alpha, bifunctionally regulated by ceramide and arachidonic acid.
    EMBO J. 1995 May 1;14(9):1961-9 PMID: 7744003
  43. Ceramide synthase mediates daunorubicin-induced apoptosis: an alternative mechanism for generating death signals.
    Cell. 1995 Aug 11;82(3):405-14 PMID: 7634330
  44. Acid sphingomyelinase deficient mice: a model of types A and B Niemann-Pick disease.
    Nat Genet. 1995 Jul;10(3):288-93 PMID: 7670466
  45. Compartmentalized production of ceramide at the cell surface.
    J Biol Chem. 1995 Nov 10;270(45):27179-85 PMID: 7592974
  46. Suppression of ceramide-mediated programmed cell death by sphingosine-1-phosphate.
    Nature. 1996 Jun 27;381(6585):800-3 PMID: 8657285
  47. Ceramide-binding and activation defines protein kinase c-Raf as a ceramide-activated protein kinase.
    Proc Natl Acad Sci U S A. 1996 Jul 9;93(14):6959-63 PMID: 8692926
  48. Cathepsin D protease mediates programmed cell death induced by interferon-gamma, Fas/APO-1 and TNF-alpha.
    EMBO J. 1996 Aug 1;15(15):3861-70 PMID: 8670891
  49. Kinase suppressor of Ras is ceramide-activated protein kinase.
    Cell. 1997 Apr 4;89(1):63-72 PMID: 9094715
  50. Association of p75(NTR) with caveolin and localization of neurotrophin-induced sphingomyelin hydrolysis to caveolae.
    J Biol Chem. 1997 Apr 18;272(16):10922-7 PMID: 9099750
  51. Secretory sphingomyelinase, a product of the acid sphingomyelinase gene, can hydrolyze atherogenic lipoproteins at neutral pH. Implications for atherosclerotic lesion development.
    J Biol Chem. 1998 Jan 30;273(5):2738-46 PMID: 9446580
  52. Mechanisms underlying nonsteroidal antiinflammatory drug-mediated apoptosis.
    Proc Natl Acad Sci U S A. 1998 Jan 20;95(2):681-6 PMID: 9435252
  53. Glutathione regulation of neutral sphingomyelinase in tumor necrosis factor-alpha-induced cell death.
    J Biol Chem. 1998 May 1;273(18):11313-20 PMID: 9556624
  54. Inhibition of the anti-apoptotic PI(3)K/Akt/Bad pathway by stress.
    Genes Dev. 1998 Jul 1;12(13):1941-6 PMID: 9649498
  55. The cellular trafficking and zinc dependence of secretory and lysosomal sphingomyelinase, two products of the acid sphingomyelinase gene.
    J Biol Chem. 1998 Jul 17;273(29):18250-9 PMID: 9660788
  56. Molecular cloning and functional characterization of murine sphingosine kinase.
    J Biol Chem. 1998 Sep 11;273(37):23722-8 PMID: 9726979
  57. Signal transduction of stress via ceramide.
    Biochem J. 1998 Nov 1;335 ( Pt 3):465-80 PMID: 9794783
  58. A pilot clinical/pharmacological study of the protein kinase C-specific inhibitor safingol alone and in combination with doxorubicin.
    Clin Cancer Res. 1997 Apr;3(4):537-43 PMID: 9815717
  59. Ataxia telangiectasia-mutated gene product inhibits DNA damage-induced apoptosis via ceramide synthase.
    J Biol Chem. 1999 Jun 18;274(25):17908-17 PMID: 10364237
  60. Ceramide induces Bcl2 dephosphorylation via a mechanism involving mitochondrial PP2A.
    J Biol Chem. 1999 Jul 16;274(29):20296-300 PMID: 10400650
  61. Inhibition of PKB/Akt1 by C2-ceramide involves activation of ceramide-activated protein phosphatase in PC12 cells.
    Mol Cell Neurosci. 2000 Feb;15(2):156-69 PMID: 10673324
Article Info
Journal
The Journal of clinical investigation
Abbr.
J Clin Invest
ISSN
0021-9738
DOI
10.1172/JCI16127
Email
r-kolesnick@ski.mskcc.org
Published
2002-07-00
Pages
3-8
Language
English
Region
United States
NLM ID
7802877
PMCID
PMC151041
Subset
IM
Grants
NCI NIH HHS · R01 CA042385 · United States
NCI NIH HHS · R01 CA085704 · United States
NCI NIH HHS · CA 85704 · United States
NCI NIH HHS · R01 CA 42385 · United States
External Links
PubMed source DOI: 10.1172/JCI16127 PMC Full Text View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: product@genelibs.com

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2