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PMID: 12080121 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Adhesion of nanoparticles to vesicles: a Brownian dynamics simulation.

Biophysical journal ·Vol. 83 ·No. 1 ·2002-07-00 ·Pages 299-308

Noguchi H, Takasu M

Abstract

We studied the interaction of bilayer vesicles and adhesive nanoparticles using a Brownian dynamics simulation. The nanoparticles are simple models of proteins or colloids. The adhering nanoparticle induces the morphological change of the vesicle: budding, formation of two vesicles in which only outer monolayers are connected, and fission. We also show that the nanoparticle promotes the fusion process: fusion-pore opening from a stalk intermediate, a neck-like structure that only connects outer monolayers of two vesicles. The nanoparticle bends the stalk, and induces the pore opening.

MeSH Terms
Biophysics/methods Cell Adhesion Lipid Bilayers/chemistry Membrane Fusion Models, Biological Models, Statistical Nanotechnology Temperature Time Factors
Chemicals
Lipid Bilayers
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Noguchi Hiroshi
Department of Applied Molecular Science, Institute for Molecular Science, Okazaki 444-8585, Japan. noguchi@ims.ac.jp
Takasu Masako
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Article Info
Journal
Biophysical journal
Abbr.
Biophys J
ISSN
0006-3495
DOI
10.1016/S0006-3495(02)75170-9
Email
noguchi@ims.ac.jp
Published
2002-07-00
Pages
299-308
Language
English
Region
United States
NLM ID
0370626
PMCID
PMC1302148
Subset
IM
External Links
PubMed source DOI: 10.1016/S0006-3495(02)75170-9 PMC Full Text View journal details
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