Abstract
During the course of meiotic prophase, intrinsic double-strand breaks (DSBs) must be repaired before the cell can engage in meiotic nuclear division. Here we investigate the mechanism that controls the meiotic progression in Schizosaccharomyces pombe that have accumulated excess meiotic DSBs. A meiotic recombination-defective mutant, meu13Delta, shows a delay in meiotic progression. This delay is dependent on rec12+, namely on DSB formation. Pulsed-field gel electrophoresis analysis revealed that meiotic DSB repair in meu13Delta was retarded. We also found that the delay in entering nuclear division was dependent on the checkpoint rad+, cds1+ and mek1+ (the meiotic paralog of Cds1/Chk2). This implies that these genes are involved in a checkpoint that provides time to repair DSBs. Consistently, the induction of an excess of extrinsic DSBs by ionizing radiation delayed meiotic progression in a rad17(+)-dependent manner. dmc1Delta also shows meiotic delay, however, this delay is independent of rec12+ and checkpoint rad+. We propose that checkpoint monitoring of the status of meiotic DSB repair exists in fission yeast and that defects other than DSB accumulation can cause delays in meiotic progression.
MeSH Terms
Blotting, Western
Cell Cycle Proteins/genetics
Cell Nucleus/metabolism
Checkpoint Kinase 2
DNA Damage
DNA Repair
DNA-Binding Proteins
Endonucleases/genetics
Gamma Rays
Gene Expression Regulation, Fungal
Meiosis
Mutation
Phosphorylation
Protein Kinases/genetics
Protein Serine-Threonine Kinases
Recombination, Genetic
Schizosaccharomyces/genetics
Schizosaccharomyces pombe Proteins/genetics
Time Factors
Chemicals
Cell Cycle Proteins
DNA-Binding Proteins
Meu13 protein, S pombe
Schizosaccharomyces pombe Proteins
rec12 protein, S pombe
rad9 protein
Protein Kinases
Checkpoint Kinase 2
Cds1 protein, S pombe
Protein Serine-Threonine Kinases
rad3 protein, S pombe
Endonucleases
rad1 protein, S pombe
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Shimada Midori
Department of Molecular Genetics, Research Institute for Microbial Diseases, Osaka University, 3-1 Yamadaoka, Suita City, Osaka 565-0871, Japan.
Nabeshima Kentaro
Tougan Takahiro
Nojima Hiroshi
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