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PMID: 12023020 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

The LGI1 gene involved in lateral temporal lobe epilepsy belongs to a new subfamily of leucine-rich repeat proteins.

FEBS letters ·Vol. 519 ·No. 1-3 ·2002-05-22 ·Pages 71-6

Gu W, Wevers A, Schröder H, Grzeschik KH, Derst C, Brodtkorb E, de Vos R, Steinlein OK

Abstract

Recently mutations in the LGI1 (leucine-rich, glioma-inactivated 1) gene have been found in human temporal lobe epilepsy. We have now identified three formerly unknown LGI-like genes. Hydropathy plots and pattern analysis showed that LGI genes encode proteins with large extra- and intracellular domains connected by a single transmembrane region. Sequence analysis demonstrated that LGI1, LGI2, LGI3, and LGI4 form a distinct subfamily when compared to other leucine-rich repeat-containing proteins. In silico mapping and radiation hybrid experiments assigned LGI2, LGI3, and LGI4 to different chromosomal regions (4p15.2, 8p21.3, 19q13.11), some of which have been implicated in epileptogenesis and/or tumorigenesis.

MeSH Terms

Adolescent Adult Child Chromosomes, Human, Pair 10/genetics Chromosomes, Human, Pair 19/genetics Chromosomes, Human, Pair 4/genetics Chromosomes, Human, Pair 8/genetics Cloning, Molecular Epilepsy, Temporal Lobe/genetics Female Frontal Lobe/cytology,metabolism Humans Intracellular Signaling Peptides and Proteins Leucine/genetics Male Middle Aged Molecular Sequence Data Multigene Family Nerve Tissue Proteins Organ Specificity Phylogeny Protein Biosynthesis Proteins/genetics,metabolism RNA, Messenger/biosynthesis Radiation Hybrid Mapping Repetitive Sequences, Amino Acid/genetics Sequence Homology, Amino Acid Temporal Lobe/cytology,metabolism

Chemicals

Intracellular Signaling Peptides and Proteins LGI1 protein, human LGI2 protein, human LGI3 protein, human Nerve Tissue Proteins Proteins RNA, Messenger Leucine

Authors & Affiliations

8 authors, click to expand affiliations / ORCID

Gu Wenli

Institute of Human Genetics, University Hospital Bonn, Wilhelmstrasse 31, Bonn, Germany.

Wevers Andrea

Schröder Hannsjörg

Grzeschik Karl Heinz

Derst Christian

Brodtkorb Eylert

de Vos Rob

Steinlein Ortrud K

Article Info

Journal

FEBS letters

Abbr.

FEBS Lett

ISSN

0014-5793

DOI

10.1016/s0014-5793(02)02713-8

Published

2002-05-22

Pages

71-6

Language

English

Region

England

NLM ID

0155157

Subset

External Links

PubMed source DOI: 10.1016/s0014-5793(02)02713-8 View journal details

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The LGI1 gene involved in lateral temporal lobe epilepsy belongs to a new subfamily of leucine-rich repeat proteins.

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