Effect of 3-mercaptopicolinic acid on gluconeogenesis and gluconeogenic metabolite concentrations in the isolated perfused rat liver.

The Biochemical journal ·Vol. 150 ·No. 1 ·1975-07-00 ·Pages 137-9

Goodman MN

Abstract

3-Mercaptopicolinic acid inhibited gluconeogenesis from lactate and alanine, but not dihydroxyacetone, in the perfused rat liver. Hepatic metabolite concentrations suggested that gluconeogenesis was inhibited at phosphoenolpyruvate carboxykinase. The compound is very effective at low concentrations, and seems an ideal agent for use in studying metabolic regulation involving gluconeogenesis and anaplerotic mechanisms.

MeSH Terms

Alanine/metabolism Animals Depression, Chemical Dihydroxyacetone/metabolism Gluconeogenesis/drug effects Lactates/metabolism Liver/metabolism Male Picolinic Acids/pharmacology Rats Sulfhydryl Compounds/pharmacology

Chemicals

Lactates Picolinic Acids Sulfhydryl Compounds Dihydroxyacetone Alanine

Authors & Affiliations

1 authors, click to expand affiliations / ORCID

Goodman M N

References (6)

6 references, click to expand

3-mercaptopicolinic acid, an inhibitor of gluconeogenesis.
Biochem J. 1974 Mar;138(3):387-94 PMID: 4429541
Influence of fluorocarbon emulsions on hepatic metabolism in perfused rat liver.
Am J Physiol. 1973 Dec;225(6):1384-8 PMID: 4760450
Influence of L-tryptophan and its metabolites on gluconeogenesis in the isolated, perfused liver.
Biochemistry. 1967 Jul;6(7):2129-38 PMID: 6049448
The regulation of gluconeogenesis. The effect of pent-4-enoic acid on gluconeogenesis and on the gluconeogenic metabolite concentrations of isolated perfused rat liver.
J Biol Chem. 1970 Feb 25;245(4):818-24 PMID: 4313610
Paths of carbon in gluconeogenesis and lipogenesis. IV. Inhibition by L-tryptophan of hepatic gluconeogenesis at the level of phosphoenolpyruvate formation.
J Biol Chem. 1966 Sep 10;241(17):3904-8 PMID: 5920802
Alteration of rat liver phosphoenolpyruvate carboxykinase activity by L-tryptophan in vivo and metals in vitro.
Biochemistry. 1967 Jul;6(7):2120-8 PMID: 6049447

Article Info

Journal

The Biochemical journal

Abbr.

Biochem J

ISSN

0264-6021

DOI

10.1042/bj1500137

Published

1975-07-00

Pages

137-9

Language

English

Region

England

NLM ID

2984726R

PMCID

PMC1165714

Subset

External Links

PubMed source DOI: 10.1042/bj1500137 PMC Full Text View journal details

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Effect of 3-mercaptopicolinic acid on gluconeogenesis and gluconeogenic metabolite concentrations in the isolated perfused rat liver.

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