The skin in magnesium-deficient rats.

Archives for dermatological research = Archiv fur dermatologische Forschung ·Vol. 254 ·No. 1 ·1975-11-14 ·Pages 1-13

Davis H, Gascho C, Kiernan JA

Abstract

The cutaneous vasodilatation occuring in the early stages of dietary deficiency of magnesium has been investigated in rats. While the time of onset of erythema varies in proportion to the weight of the animal, the duration is not related to weight. In severe states of vasodilatation, the skin is thickened and infiltrated with mononuclear cells, apparently derived from the blood. Intact sympathetic and sensory innervation are not necessary for the development of vasodilatation in the skin. Neither can the genesis of the erythema be attributed to degranulation of mast cells. From consideration of this and other investigations, it is concluded that the cutaneous abnormalities of magnesium-deficient rats cannot be due directly to hypomagnesaemia.

MeSH Terms

Animals Blood Vessels/pathology Cell Count Cytoplasmic Granules Denervation Dilatation, Pathologic Edema/etiology Erythema/etiology,pathology Exudates and Transudates Leukocytes/pathology Magnesium Deficiency/complications,pathology Male Mast Cells/pathology Rats Skin/blood supply,innervation,pathology Sympathectomy

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Davis H

Gascho C

Kiernan J A

References (15)

15 references, click to expand

Histological, histochemical and pharmacological observations on mast cells in the stomach of the rat.
J Anat. 1973 Sep;115(Pt 3):315-25 PMID: 4762130
Magnesium deficiency in the adult rat.
Biochem J. 1964 Jul;92(1):119-26 PMID: 5840376
The involvement of mast cells in vasodilatation due to axon reflexes in injured skin.
Q J Exp Physiol Cogn Med Sci. 1972 Jul;57(3):311-7 PMID: 4114011
EFFECT OF AGE ON MAGNESIUM DEFICIENCY IN RATS.
Br J Nutr. 1963;17:591-600 PMID: 14083957
Some observations on the innervation of the pinna of the ear of the rat.
J Anat. 1974 Apr;117(Pt 2):397-402 PMID: 4461730
The development of mast cells in vitro.
J Anat. 1974 Dec;118(Pt 3):517-29 PMID: 4452652
Effect of magnesium deficiency on the regeneration of mast cells after treatment with 48/80 in rats.
Can J Biochem Physiol. 1960 Jun;38:585-9 PMID: 13802224
Biochemical and pathological studies on magnesium deficiency in the rat. II. Adult animals.
J Comp Pathol. 1972 Jan;82(1):37-46 PMID: 5018038
A pharmacological and histological investigation of the involvement of mast cells in cutaneous axon reflex vasodilatation.
Q J Exp Physiol Cogn Med Sci. 1975 Apr;60(2):123-30 PMID: 1040936
Degranulation of mast cells following antidromic stimulation of cutaneous nerves.
J Anat. 1972 Feb;111(Pt 2):349-50 PMID: 5039205
Localization of alpha-D-glucosyl and alpha-D-mannosyl groups of mucosubstances with concanavalin A and horseradish peroxidase.
Histochemistry. 1975 Jul 16;44(1):39-45 PMID: 52638
The pharmacological actions of magnesium ions with particular reference to the neuromuscular and the cardiovascular system.
Pharmacol Rev. 1952 Dec;4(4):396-414 PMID: 13026406
Effect of magnesium deficiency on mast cells and urinary histamine in rats.
Br J Exp Pathol. 1963 Apr;44:151-5 PMID: 13968527
Biochemical and pathological studies on magnesium deficiency in the rat.
J Comp Pathol. 1968 Apr;78(2):149-59 PMID: 5648806
Behavior of the dermal mast cells in magnesium-deficient rats.
Science. 1957 Jul 5;126(3262):29-30 PMID: 13442641

Article Info

Journal

Archives for dermatological research = Archiv fur dermatologische Forschung

Abbr.

Arch Dermatol Res

DOI

10.1007/BF00561528

Published

1975-11-14

Pages

1-13

Language

English

Region

Germany

NLM ID

7512589

Subset

External Links

PubMed source DOI: 10.1007/BF00561528

Analysis Services

The skin in magnesium-deficient rats.

Contact

WeChat Official Account