Effect of distamycin a on the structure and template activity of DNA in RNA - polymerase system.

FEBS letters ·Vol. 7 ·No. 1 ·1970-03-16 ·Pages 90-94

Chandra P, Zimmer C, Thrum H

Abstract

It is shown that native and denatured DNA form complexes with the oligopeptide-antibiotic distamycin A. The pronounced inhibition of the incorporation of AMP into RNA in the DNA directed RNA-polymerase system is due to the interference of the antibiotic with DNA.

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Chandra P

Institut für Therapeutische Biochemie der Universität, Frankfurt an Main, GDR

Zimmer C

Thrum H

Article Info

Journal

FEBS letters

Abbr.

FEBS Lett

ISSN

1873-3468

DOI

10.1016/0014-5793(70)80626-3

Published

1970-03-16

Pages

90-94

Language

English

Region

England

NLM ID

0155157

External Links

PubMed source DOI: 10.1016/0014-5793(70)80626-3 View journal details

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Effect of distamycin a on the structure and template activity of DNA in RNA - polymerase system.

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