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Identification of a gene responsible for familial Wolff-Parkinson-White syndrome.
N Engl J Med. 2001 Jun 14;344(24):1823-31
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J Mol Cell Cardiol. 2000 Sep;32(9):1595-607
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Trends Genet. 2000 Sep;16(9):383-8
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Nat Genet. 2001 Jul;28(3):276-80
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Calcineurin plays a critical role in the development of pressure overload-induced cardiac hypertrophy.
Circulation. 2001 Jul 3;104(1):97-101
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Cell. 2001 Jun 29;105(7):851-62
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Circulation. 2001 Jul 10;104(2):131-3
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A murine model of Holt-Oram syndrome defines roles of the T-box transcription factor Tbx5 in cardiogenesis and disease.
Cell. 2001 Sep 21;106(6):709-21
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Absence of pressure overload induced myocardial hypertrophy after conditional inactivation of Galphaq/Galpha11 in cardiomyocytes.
Nat Med. 2001 Nov;7(11):1236-40
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Specific interaction of the potassium channel beta-subunit minK with the sarcomeric protein T-cap suggests a T-tubule-myofibril linking system.
J Mol Biol. 2001 Nov 2;313(4):775-84
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Suppressor of cytokine signaling-3 is a biomechanical stress-inducible gene that suppresses gp130-mediated cardiac myocyte hypertrophy and survival pathways.
J Clin Invest. 2001 Nov;108(10):1459-67
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Mediation of IGF-1-induced skeletal myotube hypertrophy by PI(3)K/Akt/mTOR and PI(3)K/Akt/GSK3 pathways.
Nat Cell Biol. 2001 Nov;3(11):1009-13
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Akt/mTOR pathway is a crucial regulator of skeletal muscle hypertrophy and can prevent muscle atrophy in vivo.
Nat Cell Biol. 2001 Nov;3(11):1014-9
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A defect in the Kv channel-interacting protein 2 (KChIP2) gene leads to a complete loss of I(to) and confers susceptibility to ventricular tachycardia.
Cell. 2001 Dec 14;107(6):801-13
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Requirement of a macromolecular signaling complex for beta adrenergic receptor modulation of the KCNQ1-KCNE1 potassium channel.
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Cardiac excitation-contraction coupling.
Nature. 2002 Jan 10;415(6868):198-205
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Seven-transmembrane-spanning receptors and heart function.
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Restoration of deficient membrane proteins in the cardiomyopathic hamster by in vivo cardiac gene transfer.
Circulation. 2002 Jan 29;105(4):502-8
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Reduced level of serine(16) phosphorylated phospholamban in the failing rat myocardium: a major contributor to reduced SERCA2 activity.
Cardiovasc Res. 2002 Feb 1;53(2):382-91
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Constitutively active AMP kinase mutations cause glycogen storage disease mimicking hypertrophic cardiomyopathy.
J Clin Invest. 2002 Feb;109(3):357-62
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Congenital heart disease caused by mutations in the transcription factor NKX2-5.
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J Mol Cell Cardiol. 1999 Mar;31(3):479-91
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Stress pathways and heart failure.
Cell. 1999 Sep 3;98(5):555-8
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Chronic phospholamban-sarcoplasmic reticulum calcium ATPase interaction is the critical calcium cycling defect in dilated cardiomyopathy.
Cell. 1999 Oct 29;99(3):313-22
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J Biol Chem. 2000 Feb 18;275(7):4693-8
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Prospects for gene therapy for heart failure.
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Genomic circuits and the integrative biology of cardiac diseases.
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A novel genetic pathway for sudden cardiac death via defects in the transition between ventricular and conduction system cell lineages.
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Decoding calcium signals involved in cardiac growth and function.
Nat Med. 2000 Nov;6(11):1221-7
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The dual-specificity phosphatase MKP-1 limits the cardiac hypertrophic response in vitro and in vivo.
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Cytoplasmic signaling pathways that regulate cardiac hypertrophy.
Annu Rev Physiol. 2001;63:391-426
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Conduction slowing and sudden arrhythmic death in mice with cardiac-restricted inactivation of connexin43.
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Molecular and cellular mechanisms of cardiac arrhythmias.
Cell. 2001 Feb 23;104(4):569-80
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Targeted inhibition of calcineurin attenuates cardiac hypertrophy in vivo.
Proc Natl Acad Sci U S A. 2001 Mar 13;98(6):3322-7
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Myocyte-enriched calcineurin-interacting protein, MCIP1, inhibits cardiac hypertrophy in vivo.
Proc Natl Acad Sci U S A. 2001 Mar 13;98(6):3328-33
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A novel role for STAT3 in cardiac remodeling.
Trends Cardiovasc Med. 2000 Oct;10(7):298-303
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Regulation of KChIP2 potassium channel beta subunit gene expression underlies the gradient of transient outward current in canine and human ventricle.
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Nature. 2001 May 17;411(6835):355-65
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Mutations in the gamma(2) subunit of AMP-activated protein kinase cause familial hypertrophic cardiomyopathy: evidence for the central role of energy compromise in disease pathogenesis.
Hum Mol Genet. 2001 May 15;10(11):1215-20
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Characterization of homo- and heterodimerization of cardiac Csx/Nkx2.5 homeoprotein.
J Biol Chem. 2001 Feb 16;276(7):4570-80
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Evidence that human cardiac myocytes divide after myocardial infarction.
N Engl J Med. 2001 Jun 7;344(23):1750-7
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Hypertension. 2001 May;37(5):1222-8
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PKA phosphorylation dissociates FKBP12.6 from the calcium release channel (ryanodine receptor): defective regulation in failing hearts.
Cell. 2000 May 12;101(4):365-76
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