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PMID: 11927020 Published · ppublish English Journal Article

Immunization with heterologous flaviviruses protective against fatal West Nile encephalitis.

Emerging infectious diseases ·Vol. 8 ·No. 3 ·2002-03-00 ·Pages 245-51

Tesh RB, Travassos da Rosa AP, Guzman H, Araujo TP, Xiao SY

Abstract

Prior immunization of hamsters with three heterologous flaviviruses (Japanese encephalitis virus [JEV] SA14-2-8 vaccine, wild-type St. Louis encephalitis virus [SLEV], and Yellow fever virus [YFV] 17D vaccine) reduces the severity of subsequent West Nile virus (WNV) infection. Groups of adult hamsters were immunized with each of the heterologous flaviviruses; approximately 30 days later, the animals were injected intraperitoneally with a virulent New York strain of WNV. Subsequent levels of viremia, antibody response, and deaths were compared with those in nonimmune (control) hamsters. Immunity to JEV and SLEV was protective against clinical encephalitis and death after challenge with WNV. The antibody response in the sequentially infected hamsters also illustrates the difficulty in making a serologic diagnosis of WNV infection in animals (or humans) with preexisting Flavivirus immunity.

MeSH Terms
Animals Antibodies, Viral/blood Antibody Formation Cricetinae Encephalitis Virus, Japanese/immunology Encephalitis Virus, St. Louis/immunology Flavivirus/immunology West Nile Fever/immunology West Nile virus/immunology
Chemicals
Antibodies, Viral
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Tesh Robert B
University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77555-0609, USA. rtesh@utmb.edu
Travassos da Rosa Amelia P A
Guzman Hilda
Araujo Tais P
Xiao Shu-Yuan
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Article Info
Journal
Emerging infectious diseases
Abbr.
Emerg Infect Dis
ISSN
1080-6040
DOI
10.3201/eid0803.010238
Email
rtesh@utmb.edu
Published
2002-03-00
Pages
245-51
Language
English
Region
United States
NLM ID
9508155
PMCID
PMC2732478
Subset
IM
External Links
PubMed source DOI: 10.3201/eid0803.010238 PMC Full Text View journal details
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