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PMID: 11914176 Published · ppublish English Journal Article Review

Genetics of early onset bipolar affective disorder: are we making progress?

Current psychiatry reports ·Vol. 4 ·No. 2 ·2002-04-00 ·Pages 141-5

Todd RD

Abstract

Though considerable progress has been made in understanding the molecular genetics of bipolar affective dis order, few studies are currently focusing on the genetics of prepubertal or early adolescent onset illness. A variety of studies of the phenomenology, imaging and comorbidity of early onset bipolarity find significant differences from late onset illness. These studies raise the notion that early onset cases may represent a distinct genetic form or forms of manic-depressive illness.

MeSH Terms
Age of Onset Bipolar Disorder/epidemiology,genetics Brain/abnormalities Genotype Humans Magnetic Resonance Imaging Prevalence
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Todd Richard D
Department of Psychiatry, Washington University School of Medicine, 660 South Euclid Avenue, Campus Box 8134, St. Louis, MO 63110, USA. toddr@psychiatry.wustl.edu
References (33)
33 references, click to expand
  1. Pharmacokinetically designed double-blind placebo-controlled study of nortriptyline in 6- to 12-year-olds with major depressive disorder.
    J Am Acad Child Adolesc Psychiatry. 1992 Jan;31(1):34-44 PMID: 1537779
  2. The Great Smoky Mountains Study of Youth. Goals, design, methods, and the prevalence of DSM-III-R disorders.
    Arch Gen Psychiatry. 1996 Dec;53(12):1129-36 PMID: 8956679
  3. Prevalence of psychopathology in children of a bipolar parent.
    J Am Acad Child Adolesc Psychiatry. 2001 Sep;40(9):1094-102 PMID: 11556634
  4. Children with prepubertal-onset major depressive disorder and anxiety grown up.
    Arch Gen Psychiatry. 1999 Sep;56(9):794-801 PMID: 12884885
  5. Attention-deficit hyperactivity disorder with bipolar disorder: a familial subtype?
    J Am Acad Child Adolesc Psychiatry. 1997 Oct;36(10):1378-87; discussion 1387-90 PMID: 9334551
  6. Decreased anterior cingulate myo-inositol/creatine spectroscopy resonance with lithium treatment in children with bipolar disorder.
    Neuropsychopharmacology. 2001 Apr;24(4):359-69 PMID: 11182531
  7. Psychiatric diagnoses in the child and adolescent members of extended families identified through adult bipolar affective disorder probands.
    J Am Acad Child Adolesc Psychiatry. 1996 May;35(5):664-71 PMID: 8935214
  8. Unmet needs in diagnosis and treatment of mood disorders in children and adolescents. Proceedings of a consensus development conference. October 17-18, 2000. Washington, DC, USA.
    Biol Psychiatry. 2001 Jun 15;49(12):959-1135 PMID: 11430836
  9. Familiality and heritability of subtypes of attention deficit hyperactivity disorder in a population sample of adolescent female twins.
    Am J Psychiatry. 2001 Nov;158(11):1891-8 PMID: 11691697
  10. Prepubertal and early adolescent bipolarity differentiate from ADHD by manic symptoms, grandiose delusions, ultra-rapid or ultradian cycling.
    J Affect Disord. 1998 Nov;51(2):81-91 PMID: 10743841
  11. Serotonin transporter gene (HTTLPR) is not in linkage disequilibrium with prepubertal and early adolescent bipolarity.
    Biol Psychiatry. 1999 May 1;45(9):1230-3 PMID: 10331118
  12. Bipolar disorders in a community sample of older adolescents: prevalence, phenomenology, comorbidity, and course.
    J Am Acad Child Adolesc Psychiatry. 1995 Apr;34(4):454-63 PMID: 7751259
  13. Attention deficit hyperactivity disorder with bipolar disorder in girls: further evidence for a familial subtype?
    J Affect Disord. 2001 Apr;64(1):19-26 PMID: 11292516
  14. Genetic studies of affective disorders: should we be starting with childhood onset probands?
    J Am Acad Child Adolesc Psychiatry. 1993 Nov;32(6):1164-71 PMID: 8282660
  15. Diagnostic and therapeutic dilemmas in the management of pediatric-onset bipolar disorder.
    J Clin Psychiatry. 2001;62 Suppl 14:10-5 PMID: 11469669
  16. A controlled family history study of childhood-onset depressive disorder.
    Arch Gen Psychiatry. 1997 Jul;54(7):613-23 PMID: 9236545
  17. Complex and rapid-cycling in bipolar children and adolescents: a preliminary study.
    J Affect Disord. 1995 Aug 18;34(4):259-68 PMID: 8550951
  18. Reliability of the Washington University in St. Louis Kiddie Schedule for Affective Disorders and Schizophrenia (WASH-U-KSADS) mania and rapid cycling sections.
    J Am Acad Child Adolesc Psychiatry. 2001 Apr;40(4):450-5 PMID: 11314571
  19. Genome scans for susceptibility genes in bipolar affective disorder.
    Ann Med. 2001 May;33(4):257-62 PMID: 11405547
  20. Latent class analysis of ADHD and comorbid symptoms in a population sample of adolescent female twins.
    J Child Psychol Psychiatry. 2001 Oct;42(7):933-42 PMID: 11693588
  21. Parameters for reliable results in genetic association studies in common disease.
    Nat Genet. 2002 Feb;30(2):149-50 PMID: 11799396
  22. Rate and predictors of prepubertal bipolarity during follow-up of 6- to 12-year-old depressed children.
    J Am Acad Child Adolesc Psychiatry. 1994 May;33(4):461-8 PMID: 8005898
  23. Ultradian rapid cycling in prepubertal and early adolescent bipolarity is not in transmission disequilibrium with val/met COMT alleles.
    Biol Psychiatry. 2000 Apr 1;47(7):605-9 PMID: 10745052
  24. Parsing pediatric bipolar disorder from its associated comorbidity with the disruptive behavior disorders.
    Biol Psychiatry. 2001 Jun 15;49(12):1062-70 PMID: 11430848
  25. Adult psychosocial outcome of prepubertal major depressive disorder.
    J Am Acad Child Adolesc Psychiatry. 2001 Jun;40(6):673-7 PMID: 11392345
  26. Depressed adolescents grown up.
    JAMA. 1999 May 12;281(18):1707-13 PMID: 10328070
  27. Bipolar disorder at prospective follow-up of adults who had prepubertal major depressive disorder.
    Am J Psychiatry. 2001 Jan;158(1):125-7 PMID: 11136645
  28. Mood disorders in children and adolescents: an epidemiologic perspective.
    Biol Psychiatry. 2001 Jun 15;49(12):1002-14 PMID: 11430842
  29. Children and adolescents with psychotic disorder not otherwise specified: a 2- to 8-year follow-up study.
    Compr Psychiatry. 2001 Jul-Aug;42(4):319-25 PMID: 11458307
  30. Epidemiology of DSM-III-R major depression and minor depression among adolescents and young adults in the National Comorbidity Survey.
    Depress Anxiety. 1998;7(1):3-14 PMID: 9592628
  31. Bipolar and antisocial disorders among relatives of ADHD children: parsing familial subtypes of illness.
    Am J Med Genet. 1998 Feb 7;81(1):108-16 PMID: 9514596
  32. Proton MR spectroscopy in children with bipolar affective disorder: preliminary observations.
    AJNR Am J Neuroradiol. 2000 May;21(5):832-8 PMID: 10815657
  33. Prevalence of affective disorder in the child and adolescent offspring of a single kindred: a pilot study.
    J Am Acad Child Adolesc Psychiatry. 1994 Feb;33(2):198-207 PMID: 8150791
Article Info
Journal
Current psychiatry reports
Abbr.
Curr Psychiatry Rep
ISSN
1523-3812
DOI
10.1007/s11920-002-0048-z
Email
toddr@psychiatry.wustl.edu
Published
2002-04-00
Pages
141-5
Language
English
Region
United States
NLM ID
100888960
Subset
IM
External Links
PubMed source DOI: 10.1007/s11920-002-0048-z View journal details
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