HIV-1 and the brain: connections between HIV-1-associated dementia, neuropathology and neuroimmunology.

Microbes and infection ·Vol. 4 ·No. 3 ·2002-03-00 ·Pages 301-8

Lawrence DM, Major EO

Abstract

AIDS patients frequently exhibit neurological disorders due to the neurotoxic events that result from HIV-1 and/or opportunistic infections in the brain. This review examines recent clinical findings related to HIV-1-associated dementia, and outlines current areas of basic research that may clarify how HIV-1-associated encephalopathy produces clinical symptoms of brain dysfunction.

MeSH Terms

AIDS Dementia Complex/immunology,pathology Brain/immunology,pathology Encephalitis, Viral/immunology HIV-1/pathogenicity Humans Models, Immunological

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Lawrence Diane M

Laboratory of Molecular Medicine and Neuroscience, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Building 36, Room 5W21, 36 Convent Drive, MSC 4164, Bethesda, MD 20892-4164, USA. lawrencd@ninds.nih.gov

Major Eugene O

Article Info

Journal

Microbes and infection

Abbr.

Microbes Infect

ISSN

1286-4579

DOI

10.1016/s1286-4579(02)01542-3

lawrencd@ninds.nih.gov

Published

2002-03-00

Pages

301-8

Language

English

Region

France

NLM ID

100883508

Subset

External Links

PubMed source DOI: 10.1016/s1286-4579(02)01542-3 View journal details

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HIV-1 and the brain: connections between HIV-1-associated dementia, neuropathology and neuroimmunology.

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