Mitotic exit: delaying the end without FEAR.

Current biology : CB ·Vol. 12 ·No. 6 ·2002-03-19 ·Pages R221-3

Jensen S, Geymonat M, Johnston LH

Abstract

Activation of Cdc14 phosphatase, controlled by a signalling cascade known as the mitotic exit network, is the final switch that drives cells from mitosis into the next cell cycle. The recent discovery of a novel network that regulates early Cdc14 activation has revealed the unexpected existence of a two-step control of mitotic exit.

MeSH Terms

Anaphase/physiology Cell Cycle Proteins/metabolism Fungal Proteins GTP-Binding Proteins/metabolism Mitosis Nuclear Proteins Protein Kinases/metabolism Protein Serine-Threonine Kinases Protein Tyrosine Phosphatases Saccharomyces cerevisiae Proteins Signal Transduction

Chemicals

CDC14 protein, S cerevisiae CDC15 protein Cell Cycle Proteins Fungal Proteins Nuclear Proteins SPO12 protein, S cerevisiae Saccharomyces cerevisiae Proteins Protein Kinases Protein Serine-Threonine Kinases CDC5 protein, S cerevisiae Protein Tyrosine Phosphatases GTP-Binding Proteins

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Jensen Sanne

Division of Yeast Genetics, National Institute for Medical Research, London, UK.

Geymonat Marco

Johnston Leland H

Article Info

Journal

Current biology : CB

Abbr.

Curr Biol

ISSN

0960-9822

DOI

10.1016/s0960-9822(02)00756-x

Published

2002-03-19

Pages

R221-3

Language

English

Region

England

NLM ID

9107782

Subset

External Links

PubMed source DOI: 10.1016/s0960-9822(02)00756-x View journal details

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Mitotic exit: delaying the end without FEAR.

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