Ribosome structure and the mechanism of translation.

Cell ·Vol. 108 ·No. 4 ·2002-02-22 ·Pages 557-72

Ramakrishnan V

Abstract

The publication of crystal structures of the 50S and 30S ribosomal subunits and the intact 70S ribosome is revolutionizing our understanding of protein synthesis. This review is an attempt to correlate the structures with biochemical and genetic data to identify the gaps and limits in our current knowledge of the mechanisms involved in translation.

MeSH Terms

Bacteria/genetics Bacterial Proteins/metabolism Models, Genetic Models, Molecular Peptide Chain Elongation, Translational Peptide Elongation Factor Tu/metabolism Peptide Initiation Factors/metabolism Peptide Termination Factors/metabolism Peptidyl Transferases/metabolism Protein Biosynthesis Protein Structure, Quaternary Protein Subunits RNA, Messenger/metabolism Ribosomes/chemistry,metabolism

Chemicals

Bacterial Proteins Peptide Initiation Factors Peptide Termination Factors Protein Subunits RNA, Messenger Peptidyl Transferases Peptide Elongation Factor Tu

Authors & Affiliations

1 authors, click to expand affiliations / ORCID

Ramakrishnan V

MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, United Kingdom. ramak@mrc-lmb.cam.ac.uk

Article Info

Journal

Cell

Abbr.

Cell

ISSN

0092-8674

DOI

10.1016/s0092-8674(02)00619-0

ramak@mrc-lmb.cam.ac.uk

Published

2002-02-22

Pages

557-72

Language

English

Region

United States

NLM ID

0413066

Subset

External Links

PubMed source DOI: 10.1016/s0092-8674(02)00619-0 View journal details

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