Cancer gene therapy: fringe or cutting edge?

Nature reviews. Cancer ·Vol. 1 ·No. 2 ·2001-11-00 ·Pages 130-41

McCormick F

Abstract

Direct targeting of cancer cells with gene therapy has the potential to treat cancer on the basis of its molecular characteristics. But although laboratory results have been extremely encouraging, many practical obstacles need to be overcome before gene therapy can fulfil its goals in the clinic. These issues are not trivial, but seem less formidable than the challenge of killing cancers selectively and rationally--a challenge that has been successfully addressed.

MeSH Terms

Animals Apoptosis/genetics Biotransformation/genetics Bystander Effect Clinical Trials, Phase I as Topic Clinical Trials, Phase II as Topic Defective Viruses/genetics Enzyme Inhibitors/pharmacology,therapeutic use Enzymes/genetics,metabolism Female Forecasting Gene Expression Regulation, Neoplastic/genetics Genes, BRCA1 Genes, Tumor Suppressor Genes, p53 Genetic Therapy/trends Genetic Vectors/genetics,immunology,physiology,therapeutic use Herpesviridae/genetics,immunology,physiology Humans Mastadenovirus/genetics,physiology Mice Mice, Knockout Mice, Transgenic Neoplasms/genetics,therapy Neoplasms, Experimental/genetics,therapy Oncogenes Ovarian Neoplasms/genetics,therapy Prodrugs/pharmacokinetics,therapeutic use Virus Replication

Chemicals

Enzyme Inhibitors Enzymes Prodrugs

Authors & Affiliations

1 authors, click to expand affiliations / ORCID

McCormick F

University of California San Francisco, Cancer Research Institute, 94115, USA. mccormick@cc.ucsf.edu

Article Info

Journal

Nature reviews. Cancer

Abbr.

Nat Rev Cancer

ISSN

1474-175X

DOI

10.1038/35101008

mccormick@cc.ucsf.edu

Published

2001-11-00

Pages

130-41

Language

English

Region

England

NLM ID

101124168

Subset

External Links

PubMed source DOI: 10.1038/35101008 View journal details

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Cancer gene therapy: fringe or cutting edge?

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