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PMID: 11902573 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Review

The promise of retinoids to fight against cancer.

Nature reviews. Cancer ·Vol. 1 ·No. 3 ·2001-12-00 ·Pages 181-93

Altucci L, Gronemeyer H

Abstract

Retinoids have a reputation for being both detrimental and beneficial: they are teratogens, but they also have tumour-suppressive capacity. Cell biology and genetics have significantly improved our understanding of the mechanisms that underlie the anti-proliferative action of retinoids. Recent elucidation of the pathways that are activated by retinoids will help us to exploit the beneficial aspects of this powerful class of compounds for cancer therapy and prevention.

MeSH Terms

Anticarcinogenic Agents/pharmacology,therapeutic use Antineoplastic Agents/pharmacology,therapeutic use Apoptosis/drug effects Cell Differentiation/drug effects Dimerization Forecasting Gene Expression Regulation, Neoplastic/drug effects Humans Leukemia, Promyelocytic, Acute/drug therapy,genetics Models, Biological Morphogenesis/drug effects Neoplasm Proteins/antagonists & inhibitors,genetics,physiology Neoplasms/drug therapy,genetics,prevention & control Oncogene Proteins, Fusion/antagonists & inhibitors,genetics,physiology Receptor Cross-Talk Receptors, Retinoic Acid/chemistry,drug effects,physiology Retinoids/chemistry,pharmacology,therapeutic use Skin Neoplasms/chemically induced,genetics,prevention & control Structure-Activity Relationship Transcription Factor AP-1/antagonists & inhibitors Transcriptional Activation/drug effects Vitamin A/pharmacokinetics,physiology

Chemicals

Anticarcinogenic Agents Antineoplastic Agents Neoplasm Proteins Oncogene Proteins, Fusion Receptors, Retinoic Acid Retinoids Transcription Factor AP-1 promyelocytic leukemia-retinoic acid receptor alpha fusion oncoprotein Vitamin A

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Altucci L

Dipartimento di Patologia Generale e Oncologia, Seconda Università degli Studi di Napoli, Italy. lucia.altucci@unina2.it

Gronemeyer H

Article Info

Journal

Nature reviews. Cancer

Abbr.

Nat Rev Cancer

ISSN

1474-175X

DOI

10.1038/35106036

lucia.altucci@unina2.it

Published

2001-12-00

Pages

181-93

Language

English

Region

England

NLM ID

101124168

Subset

External Links

PubMed source DOI: 10.1038/35106036 View journal details

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