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PMID: 11901194 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Transient receptor potential 1 regulates capacitative Ca(2+) entry and Ca(2+) release from endoplasmic reticulum in B lymphocytes.

The Journal of experimental medicine ·Vol. 195 ·No. 6 ·2002-03-18 ·Pages 673-81

Mori Y, Wakamori M, Miyakawa T, Hermosura M, Hara Y, Nishida M, Hirose K, Mizushima A, Kurosaki M, Mori E, Gotoh K, Okada T, Fleig A, Penner R, Iino M, Kurosaki T

Abstract

Capacitative Ca(2+) entry (CCE) activated by release/depletion of Ca(2+) from internal stores represents a major Ca(2+) influx mechanism in lymphocytes and other nonexcitable cells. Despite the importance of CCE in antigen-mediated lymphocyte activation, molecular components constituting this mechanism remain elusive. Here we demonstrate that genetic disruption of transient receptor potential (TRP)1 significantly attenuates both Ca(2+) release-activated Ca(2+) currents and inositol 1,4,5-trisphosphate (IP(3))-mediated Ca(2+) release from endoplasmic reticulum (ER) in DT40 B cells. As a consequence, B cell antigen receptor-mediated Ca(2+) oscillations and NF-AT activation are reduced in TRP1-deficient cells. Thus, our results suggest that CCE channels, whose formation involves TRP1 as an important component, modulate IP(3) receptor function, thereby enhancing functional coupling between the ER and plasma membrane in transduction of intracellular Ca(2+) signaling in B lymphocytes.

MeSH Terms
Animals B-Lymphocytes/metabolism,ultrastructure Calcium/metabolism Calcium Channels/genetics,metabolism Calcium Signaling/genetics Cell Line Chickens Endoplasmic Reticulum/metabolism Gene Deletion Humans TRPC Cation Channels
Chemicals
Calcium Channels TRPC Cation Channels transient receptor potential cation channel, subfamily C, member 1 Calcium
Authors & Affiliations
16 authors, click to expand affiliations / ORCID
Mori Yasuo
Center for Integrative Bioscience, Department of Information Physiology, National Institute for Physiological Sciences, Myodaiji-cho, Okazaki 444-8585, Japan. moriy@nips.ac.jp
Wakamori Minoru
Miyakawa Tomoya
Hermosura Meredith
Hara Yuji
Nishida Motohiro
Hirose Kenzo
Mizushima Akiko
Kurosaki Mari
Mori Emiko
Gotoh Kumiko
Okada Takaharu
Fleig Andrea
Penner Reinhold
Iino Masamitsu
Kurosaki Tomohiro
References (48)
48 references, click to expand
  1. trp, a novel mammalian gene family essential for agonist-activated capacitative Ca2+ entry.
    Cell. 1996 May 31;85(5):661-71 PMID: 8646775
  2. Molecular cloning of a widely expressed human homologue for the Drosophila trp gene.
    FEBS Lett. 1995 Oct 16;373(3):193-8 PMID: 7589464
  3. Severe combined immunodeficiency due to defective binding of the nuclear factor of activated T cells in T lymphocytes of two male siblings.
    Eur J Immunol. 1996 Sep;26(9):2119-26 PMID: 8814256
  4. Differential activation of transcription factors induced by Ca2+ response amplitude and duration.
    Nature. 1997 Apr 24;386(6627):855-8 PMID: 9126747
  5. The store-operated calcium current I(CRAC): nonlinear activation by InsP3 and dissociation from calcium release.
    Cell. 1997 Jun 13;89(6):973-80 PMID: 9200615
  6. Genetic evidence for involvement of type 1, type 2 and type 3 inositol 1,4,5-trisphosphate receptors in signal transduction through the B-cell antigen receptor.
    EMBO J. 1997 Jun 2;16(11):3078-88 PMID: 9214625
  7. A multivalent PDZ-domain protein assembles signalling complexes in a G-protein-coupled cascade.
    Nature. 1997 Jul 17;388(6639):243-9 PMID: 9230432
  8. Differential distribution of TRP Ca2+ channel isoforms in mouse brain.
    Neuroreport. 1998 Feb 16;9(3):507-15 PMID: 9512398
  9. Calcium oscillations increase the efficiency and specificity of gene expression.
    Nature. 1998 Apr 30;392(6679):933-6 PMID: 9582075
  10. Cell-permeant caged InsP3 ester shows that Ca2+ spike frequency can optimize gene expression.
    Nature. 1998 Apr 30;392(6679):936-41 PMID: 9582076
  11. Calcium--a life and death signal.
    Nature. 1998 Oct 15;395(6703):645-8 PMID: 9790183
  12. Polyunsaturated fatty acids activate the Drosophila light-sensitive channels TRP and TRPL.
    Nature. 1999 Jan 21;397(6716):255-9 PMID: 9930700
  13. Encoding of Ca2+ signals by differential expression of IP3 receptor subtypes.
    EMBO J. 1999 Mar 1;18(5):1303-8 PMID: 10064596
  14. Activation of store-operated Ca2+ current in Xenopus oocytes requires SNAP-25 but not a diffusible messenger.
    Cell. 1999 Aug 20;98(4):475-85 PMID: 10481912
  15. Store-operated Ca2+ entry: evidence for a secretion-like coupling model.
    Cell. 1999 Aug 20;98(4):487-99 PMID: 10481913
  16. Molecular and functional characterization of a novel mouse transient receptor potential protein homologue TRP7. Ca(2+)-permeable cation channel that is constitutively activated and enhanced by stimulation of G protein-coupled receptor.
    J Biol Chem. 1999 Sep 24;274(39):27359-70 PMID: 10488066
  17. The N-terminal domain of the IP3 receptor gates store-operated hTrp3 channels.
    Mol Cell. 1999 Sep;4(3):423-9 PMID: 10518223
  18. Modulation of Ca(2+) entry by polypeptides of the inositol 1,4, 5-trisphosphate receptor (IP3R) that bind transient receptor potential (TRP): evidence for roles of TRP and IP3R in store depletion-activated Ca(2+) entry.
    Proc Natl Acad Sci U S A. 1999 Dec 21;96(26):14955-60 PMID: 10611319
  19. Trp1, a candidate protein for the store-operated Ca(2+) influx mechanism in salivary gland cells.
    J Biol Chem. 2000 Feb 4;275(5):3403-11 PMID: 10652333
  20. Requirement of the inositol trisphosphate receptor for activation of store-operated Ca2+ channels.
    Science. 2000 Mar 3;287(5458):1647-51 PMID: 10698739
  21. From worm to man: three subfamilies of TRP channels.
    Trends Neurosci. 2000 Apr;23(4):159-66 PMID: 10717675
  22. Assembly of Trp1 in a signaling complex associated with caveolin-scaffolding lipid raft domains.
    J Biol Chem. 2000 Apr 21;275(16):11934-42 PMID: 10766822
  23. Coassembly of Trp1 and Trp3 proteins generates diacylglycerol- and Ca2+-sensitive cation channels.
    J Biol Chem. 2000 Sep 8;275(36):27799-805 PMID: 10882720
  24. Gating of store-operated channels by conformational coupling to ryanodine receptors.
    Mol Cell. 2000 Aug;6(2):421-31 PMID: 10983988
  25. Involvement of LAT, Gads, and Grb2 in compartmentation of SLP-76 to the plasma membrane.
    J Exp Med. 2000 Sep 18;192(6):847-56 PMID: 10993915
  26. Regulation of the phospholipase C-gamma2 pathway in B cells.
    Immunol Rev. 2000 Aug;176:19-29 PMID: 11043765
  27. Negative control of store-operated Ca2+ influx by B cell receptor cross-linking.
    J Immunol. 2001 Jan 15;166(2):1003-8 PMID: 11145679
  28. Evidence that the TRP-1 protein is unlikely to account for store-operated Ca2+ inflow in Xenopus laevis oocytes.
    Mol Cell Biochem. 2000 Nov;214(1-2):63-74 PMID: 11195791
  29. Activation of calcium entry in human carcinoma A431 cells by store depletion and phospholipase C- dependent mechanisms converge on ICRAC-like calcium channels.
    Proc Natl Acad Sci U S A. 2001 Jan 2;98(1):148-53 PMID: 11136251
  30. Signaling through calcium, calcineurin, and NF-AT in lymphocyte activation and development.
    Cold Spring Harb Symp Quant Biol. 1999;64:505-16 PMID: 11232327
  31. Transcriptional regulation in lymphocytes.
    Curr Opin Cell Biol. 2001 Apr;13(2):239-43 PMID: 11248559
  32. Gene regulation mediated by calcium signals in T lymphocytes.
    Nat Immunol. 2001 Apr;2(4):316-24 PMID: 11276202
  33. Ca(2+)-sensor region of IP(3) receptor controls intracellular Ca(2+) signaling.
    EMBO J. 2001 Apr 2;20(7):1674-80 PMID: 11285231
  34. A store-operated nonselective cation channel in lymphocytes is activated directly by Ca(2+) influx factor and diacylglycerol.
    Am J Physiol Cell Physiol. 2001 May;280(5):C1284-92 PMID: 11287342
  35. TRPC1 and TRPC5 form a novel cation channel in mammalian brain.
    Neuron. 2001 Mar;29(3):645-55 PMID: 11301024
  36. Properties of a native cation channel activated by Ca2+ store depletion in vascular smooth muscle cells.
    J Biol Chem. 2001 Mar 16;276(11):7782-90 PMID: 11113149
  37. Permeation of monovalent cations through the non-capacitative arachidonate-regulated Ca2+ channels in HEK293 cells. Comparison with endogenous store-operated channels.
    J Biol Chem. 2001 Jun 15;276(24):21365-74 PMID: 11285268
  38. Identification of common binding sites for calmodulin and inositol 1,4,5-trisphosphate receptors on the carboxyl termini of trp channels.
    J Biol Chem. 2001 Jun 15;276(24):21303-10 PMID: 11290752
  39. Regulation of Ca2+-release-activated Ca2+ current (Icrac) by ryanodine receptors in inositol 1,4,5-trisphosphate-receptor-deficient DT40 cells.
    Biochem J. 2001 Nov 15;360(Pt 1):17-22 PMID: 11695987
  40. Depletion of intracellular calcium stores activates a calcium current in mast cells.
    Nature. 1992 Jan 23;355(6358):353-6 PMID: 1309940
  41. Mitogen-regulated Ca2+ current of T lymphocytes is activated by depletion of intracellular Ca2+ stores.
    Proc Natl Acad Sci U S A. 1993 Jul 1;90(13):6295-9 PMID: 8392195
  42. The signal for capacitative calcium entry.
    Cell. 1993 Oct 22;75(2):199-201 PMID: 8402906
  43. Tyrosine kinases Lyn and Syk regulate B cell receptor-coupled Ca2+ mobilization through distinct pathways.
    EMBO J. 1994 Mar 15;13(6):1341-9 PMID: 8137818
  44. Receptor-activated Ca2+ influx: how many mechanisms for how many channels?
    Trends Pharmacol Sci. 1994 Mar;15(3):77-83 PMID: 8184490
  45. The calcium current activated by T cell receptor and store depletion in human lymphocytes is absent in a primary immunodeficiency.
    J Biol Chem. 1994 Dec 23;269(51):32327-35 PMID: 7798233
  46. Calcium signaling.
    Cell. 1995 Jan 27;80(2):259-68 PMID: 7834745
  47. TRPC1, a human homolog of a Drosophila store-operated channel.
    Proc Natl Acad Sci U S A. 1995 Oct 10;92(21):9652-6 PMID: 7568191
  48. Cloning and functional expression of a human Ca2+-permeable cation channel activated by calcium store depletion.
    Neuron. 1996 Jun;16(6):1189-96 PMID: 8663995
Article Info
Journal
The Journal of experimental medicine
Abbr.
J Exp Med
ISSN
0022-1007
DOI
10.1084/jem.20011758
Email
moriy@nips.ac.jp
Published
2002-03-18
Pages
673-81
Language
English
Region
United States
NLM ID
2985109R
PMCID
PMC2193746
Subset
IM
External Links
PubMed source DOI: 10.1084/jem.20011758 PMC Full Text View journal details
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