Complement dependence of localisation of aggregated IgG in germinal centres.

Scandinavian journal of immunology ·Vol. 4 ·No. 4 ·1975-00-00 ·Pages 343-47

Papamichail M, Gutierrez C, Embling P, Johnson P, Holborow EJ, Pepys MB

Abstract

In vivo decomplementation of mice with cobra factor completely prevented trapping of aggregated human IgG within splenic germinal centres. Observations of the intrasplenic position of the aggregated material within 8 hr of its injection into normal and decomplemented mice suggest that the early phase of localisation in germinal centres depends on binding to lymphocyte C3 receptors.

MeSH Terms

Animals Binding Sites Complement C3/metabolism Complement System Proteins/metabolism Female Germ Cells/immunology Hot Temperature Immunoglobulin G/metabolism Injections, Intraperitoneal Male Mice Mice, Inbred BALB C Snake Venoms/administration & dosage,pharmacology Spleen/immunology

Chemicals

Complement C3 Immunoglobulin G Snake Venoms Complement System Proteins

Authors & Affiliations

6 authors, click to expand affiliations / ORCID

Papamichail M

Gutierrez C

Embling P

Johnson P

Holborow E J

Pepys M B

Article Info

Journal

Scandinavian journal of immunology

Abbr.

Scand J Immunol

ISSN

0300-9475

DOI

10.1111/j.1365-3083.1975.tb02635.x

Published

1975-00-00

Pages

343-47

Language

English

Region

England

NLM ID

0323767

Subset

External Links

PubMed source DOI: 10.1111/j.1365-3083.1975.tb02635.x View journal details

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