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PMID: 11879630 Published · ppublish English Journal Article Review

Apoptosome: the seven-spoked death machine.

Developmental cell ·Vol. 2 ·No. 3 ·2002-03-00 ·Pages 256-7

Salvesen GS, Renatus M

Abstract

A paper in the February issue of Molecular Cell describes the structure of the apoptosome, a multicomponent death machine, deciphered by cryoelectron microscopy. This structure explains the assembly of the machine, the tentative location of the subcomponents, and proposes a mechanism for initiating the death signal.

MeSH Terms
Animals Apoptosis/physiology Caspases/metabolism
Chemicals
Caspases
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Salvesen Guy S
Program in Apoptosis and Cell Death Research, The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA.
Renatus Martin
Article Info
Journal
Developmental cell
Abbr.
Dev Cell
ISSN
1534-5807
DOI
10.1016/s1534-5807(02)00137-5
Published
2002-03-00
Pages
256-7
Language
English
Region
United States
NLM ID
101120028
Subset
IM
External Links
PubMed source DOI: 10.1016/s1534-5807(02)00137-5 View journal details
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