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PMID: 11879555 Published · ppublish English Journal Article Review

Direct effects of bisphosphonates on breast cancer cells.

Breast cancer research : BCR ·Vol. 4 ·No. 1 ·2002-00-00 ·Pages 18-23

Senaratne SG, Colston KW

Abstract

In addition to inhibiting bone resorption, bisphosphonates have also been shown to exhibit antitumour effects. In vitro, bisphosphonates inhibit proliferation and induce apoptosis in cultured human breast cancer cells. In addition, bisphosphonate treatment interferes with breast cancer cell adhesion to bone matrix, and inhibits cell migration and invasion. The combination of bisphosphonates with other anticancer drugs such as the taxoids markedly enhances these effects. These newly recognized direct actions of bisphosphonates on breast cancer cells indicate that these agents may have a greater role to play in treatment of patients suffering from cancers with a propensity to metastasize to bone.

MeSH Terms
Antineoplastic Agents/pharmacology,therapeutic use Apoptosis/drug effects Breast Neoplasms/prevention & control Cell Adhesion/drug effects Diphosphonates/pharmacology,therapeutic use Female Humans Tumor Cells, Cultured/drug effects
Chemicals
Antineoplastic Agents Diphosphonates
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Senaratne Siddhika G
Department of Oncology, Gastroenterology, Endocrinology, and Metabolism, St George's Hospital Medical School, Cranmer Terrace, London, UK.
Colston Kay W
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Article Info
Journal
Breast cancer research : BCR
Abbr.
Breast Cancer Res
ISSN
1465-5411
DOI
10.1186/bcr412
Published
2002-00-00
Epub
2001-00-14
Pages
18-23
Language
English
Region
England
NLM ID
100927353
PMCID
PMC138711
Subset
IM
External Links
PubMed source DOI: 10.1186/bcr412 PMC Full Text View journal details
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