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题目:: Screening for oesophageal neoplasia in patients with head and neck cancer.
作者:: Scherübl(H),von Lampe(B),Faiss(S),Däubler(P),Bohlmann(P),Plath(T),Foss(H-D),Scherer(H),Strunz(A),Hoffmeister(B),Stein(H),Zeitz(M),Riecken(E-O)
状态:: 发布时间2002-02-28 , 更新时间 2014-06-13
期刊:: Br J Cancer
摘要:: Due to advanced disease at the time of diagnosis the prognosis of oesophageal cancer is generally poor. As mass screening for oesophageal cancer is neither feasible nor reasonable, high-risk groups should be identified and surveilled. The aim of this study was to define the risk of oesophageal cancer in patients with (previous) head and neck cancer. A total of 148 patients with (previous) head and neck cancer were prospectively screened for oesophageal cancer by video-oesophagoscopy and random oesophageal biopsies. Even in a macroscopically normal looking oesophagus, four biopsy specimens were taken every 3 cm throughout the entire length of the squamous oesophagus. Low- or high-grade squamous cell dysplasia was detected histologically in 10 of the 148 patients (6.8%). All but one dysplasias were diagnosed synchronously with the head and neck cancers. In addition, oesophageal squamous cell carcinoma was diagnosed in 11 of the 148 patients (7.4%). Most invasive cancers (63.6%) occurred metachronously. The risk of squamous cell neoplasia of the oesophagus is high in patients with (previous) head and neck cancer. Surveillance is recommended in this high-risk group.
语言:: eng
DOI:

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