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题目:: BAFFled B cells survive and thrive: roles of BAFF in B-cell development.
作者:: Rolink(Antonius G),Melchers(Fritz)
状态:: 发布时间2002-02-28 , 更新时间 2006-11-15
期刊:: Curr Opin Immunol
摘要:: Interactions of BAFF (B-cell activating factor) with BAFF-R, one of three BAFF-binding receptors that are preferentially expressed on B cells, are essential for B-cell development, because defects in either the ligand or the receptor arrest progression from immature type-1 B cells to type-2 cells and mature cells; B1 B cells are unaffected. Transgenic BAFF overexpression leads to B-cell hyperplasia and autoimmune disease. In vitro, BAFF increases survival of immature and mature B cells; immature B cells also mature polyclonally to mature B cells, without proliferation. Upon BAFF-influenced differentiation, immature B cells change their surface-IgM signal transduction machinery and proliferate rather than undergoing apoptosis.
语言:: eng
DOI:

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