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PMID: 11866586 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S.

SCMTR: a chloride-selective, membrane-anchored peptide channel that exhibits voltage gating.

Journal of the American Chemical Society ·Vol. 124 ·No. 9 ·2002-03-06 ·Pages 1848-9

Schlesinger PH, Ferdani R, Liu J, Pajewska J, Pajewski R, Saito M, Shabany H, Gokel GW

Abstract

The design, synthesis, and characterization of a synthetic chloride membrane transporter, SCMTR (synthetic chloride membrane transporter, "scimitar"), are presented. The compound [CH3(CH2)17]2NCOCH2OCH2CO-GGGPGGG-OBzl inserts rapidly into liposomes and planar lipid bilayers. SCMTR has a 1.3 +/- 0.01 nS chloride diffusion pathway (>10:1 Cl/K selectivity). Evidence was also obtained for voltage gating behavior.

MeSH Terms

Chloride Channels/chemical synthesis,chemistry Ion Channel Gating Lipid Bilayers/chemistry Liposomes/chemistry Membrane Potentials Phospholipids/chemistry

Chemicals

Chloride Channels Lipid Bilayers Liposomes Phospholipids

Authors & Affiliations

8 authors, click to expand affiliations / ORCID

Schlesinger Paul H

Department of Cell Biology and Physiology, Washington University School of Medicine, 660 South Euclid Avenue, St. Louis, Missouri 63110, USA.

Ferdani Riccardo

Liu Jun

Pajewska Jolanta

Pajewski Robert

Saito Mitsuyoshi

Shabany Hossein

Gokel George W

Article Info

Journal

Journal of the American Chemical Society

Abbr.

J Am Chem Soc

ISSN

0002-7863

DOI

10.1021/ja016784d

Published

2002-03-06

Pages

1848-9

Language

English

Region

United States

NLM ID

7503056

Subset

Grants

NIGMS NIH HHS · GM 36262 · United States

External Links

PubMed source DOI: 10.1021/ja016784d View journal details

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SCMTR: a chloride-selective, membrane-anchored peptide channel that exhibits voltage gating.

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