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PMID: 11864595 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S. Review

CtBP, an unconventional transcriptional corepressor in development and oncogenesis.

Molecular cell ·Vol. 9 ·No. 2 ·2002-02-00 ·Pages 213-24

Chinnadurai G

Abstract

CtBP family proteins are conserved among vertebrates and invertebrates and function as transcriptional corepressors. They repress transcription in a histone deacetylase-dependent or -independent manner. CtBPs play important roles during development and oncogenesis. In this review, their unusual properties, the mechanisms of transcriptional repression, regulation, and their biological functions are discussed.

MeSH Terms
Acetylation Adenovirus E1A Proteins/metabolism Alcohol Oxidoreductases/chemistry Amino Acid Motifs Animals BRCA1 Protein/physiology Cell Transformation, Neoplastic/genetics Conserved Sequence DNA-Binding Proteins/chemistry,genetics,physiology Drosophila Proteins/genetics,physiology Drosophila melanogaster/genetics,metabolism Gene Expression Regulation, Developmental/physiology Histone Deacetylases/metabolism Histones/metabolism Humans MDS1 and EVI1 Complex Locus Protein Macromolecular Substances Oncogenes Phosphoproteins/chemistry,physiology Phosphorylation Protein Binding Protein Processing, Post-Translational Proto-Oncogene Proteins/physiology Proto-Oncogenes Repressor Proteins/chemistry,classification Retinoblastoma Protein/physiology Transcription Factors Transcription, Genetic Vertebrates/genetics,metabolism Wnt Proteins Xenopus laevis/embryology,genetics Zebrafish Proteins ras Proteins/physiology
Chemicals
Adenovirus E1A Proteins BRCA1 Protein DNA-Binding Proteins Drosophila Proteins Histones MDS1 and EVI1 Complex Locus Protein MECOM protein, human Macromolecular Substances Phosphoproteins Proto-Oncogene Proteins Repressor Proteins Retinoblastoma Protein Transcription Factors Wnt Proteins Zebrafish Proteins Alcohol Oxidoreductases 2-hydroxyacid dehydrogenase C-terminal binding protein Histone Deacetylases ras Proteins
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Chinnadurai G
Institute for Molecular Virology, Saint Louis University School of Medicine, 3681 Park Avenue, St. Louis, MO 63110, USA. chinnag@slu.edu
Article Info
Journal
Molecular cell
Abbr.
Mol Cell
ISSN
1097-2765
Published
2002-02-00
Pages
213-24
Language
English
Region
United States
NLM ID
9802571
Subset
IM
Grants
NCI NIH HHS · CA-84941 · United States
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