Abstract
CtBP family proteins are conserved among vertebrates and invertebrates and function as transcriptional corepressors. They repress transcription in a histone deacetylase-dependent or -independent manner. CtBPs play important roles during development and oncogenesis. In this review, their unusual properties, the mechanisms of transcriptional repression, regulation, and their biological functions are discussed.
MeSH Terms
Acetylation
Adenovirus E1A Proteins/metabolism
Alcohol Oxidoreductases/chemistry
Amino Acid Motifs
Animals
BRCA1 Protein/physiology
Cell Transformation, Neoplastic/genetics
Conserved Sequence
DNA-Binding Proteins/chemistry,genetics,physiology
Drosophila Proteins/genetics,physiology
Drosophila melanogaster/genetics,metabolism
Gene Expression Regulation, Developmental/physiology
Histone Deacetylases/metabolism
Histones/metabolism
Humans
MDS1 and EVI1 Complex Locus Protein
Macromolecular Substances
Oncogenes
Phosphoproteins/chemistry,physiology
Phosphorylation
Protein Binding
Protein Processing, Post-Translational
Proto-Oncogene Proteins/physiology
Proto-Oncogenes
Repressor Proteins/chemistry,classification
Retinoblastoma Protein/physiology
Transcription Factors
Transcription, Genetic
Vertebrates/genetics,metabolism
Wnt Proteins
Xenopus laevis/embryology,genetics
Zebrafish Proteins
ras Proteins/physiology
Chemicals
Adenovirus E1A Proteins
BRCA1 Protein
DNA-Binding Proteins
Drosophila Proteins
Histones
MDS1 and EVI1 Complex Locus Protein
MECOM protein, human
Macromolecular Substances
Phosphoproteins
Proto-Oncogene Proteins
Repressor Proteins
Retinoblastoma Protein
Transcription Factors
Wnt Proteins
Zebrafish Proteins
Alcohol Oxidoreductases
2-hydroxyacid dehydrogenase
C-terminal binding protein
Histone Deacetylases
ras Proteins
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Chinnadurai G
Institute for Molecular Virology, Saint Louis University School of Medicine, 3681 Park Avenue, St. Louis, MO 63110, USA. chinnag@slu.edu