Home LiteratureArticle Details
PMID: 11859360 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

The genome sequence of Schizosaccharomyces pombe.

Nature ·Vol. 415 ·No. 6874 ·2002-02-21 ·Pages 871-80

Wood V, Gwilliam R, Rajandream MA, Lyne M, Lyne R, Stewart A, Sgouros J, Peat N, Hayles J, Baker S, Basham D, Bowman S, Brooks K, Brown D, Brown S, Chillingworth T, Churcher C, Collins M, Connor R, Cronin A, Davis P, Feltwell T, Fraser A, Gentles S, Goble A, Hamlin N, Harris D, Hidalgo J, Hodgson G, Holroyd S, Hornsby T, Howarth S, Huckle EJ, Hunt S, Jagels K, James K, Jones L, Jones M, Leather S, McDonald S, McLean J, Mooney P, Moule S, Mungall K, Murphy L, Niblett D, Odell C, Oliver K, O'Neil S, Pearson D, Quail MA, Rabbinowitsch E, Rutherford K, Rutter S, Saunders D, Seeger K, Sharp S, Skelton J, Simmonds M, Squares R, Squares S, Stevens K, Taylor K, Taylor RG, Tivey A, Walsh S, Warren T, Whitehead S, Woodward J, Volckaert G, Aert R, Robben J, Grymonprez B, Weltjens I, Vanstreels E, Rieger M, Schäfer M, Müller-Auer S, Gabel C, Fuchs M, Düsterhöft A, Fritzc C, Holzer E, Moestl D, Hilbert H, Borzym K, Langer I, Beck A, Lehrach H, Reinhardt R, Pohl TM, Eger P, Zimmermann W, Wedler H, Wambutt R, Purnelle B, Goffeau A, Cadieu E, Dréano S, Gloux S, Lelaure V, Mottier S, Galibert F, Aves SJ, Xiang Z, Hunt C, Moore K, Hurst SM, Lucas M, Rochet M, Gaillardin C, Tallada VA, Garzon A, Thode G, Daga RR, Cruzado L, Jimenez J, Sánchez M, del Rey F, Benito J, Domínguez A, Revuelta JL, Moreno S, Armstrong J, Forsburg SL, Cerutti L, Lowe T, McCombie WR, Paulsen I, Potashkin J, Shpakovski GV, Ussery D, Barrell BG, Nurse P, Cerrutti L

Abstract

We have sequenced and annotated the genome of fission yeast (Schizosaccharomyces pombe), which contains the smallest number of protein-coding genes yet recorded for a eukaryote: 4,824. The centromeres are between 35 and 110 kilobases (kb) and contain related repeats including a highly conserved 1.8-kb element. Regions upstream of genes are longer than in budding yeast (Saccharomyces cerevisiae), possibly reflecting more-extended control regions. Some 43% of the genes contain introns, of which there are 4,730. Fifty genes have significant similarity with human disease genes; half of these are cancer related. We identify highly conserved genes important for eukaryotic cell organization including those required for the cytoskeleton, compartmentation, cell-cycle control, proteolysis, protein phosphorylation and RNA splicing. These genes may have originated with the appearance of eukaryotic life. Few similarly conserved genes that are important for multicellular organization were identified, suggesting that the transition from prokaryotes to eukaryotes required more new genes than did the transition from unicellular to multicellular organization.

MeSH Terms
Base Sequence Centromere Chromosome Mapping Chromosomes, Fungal DNA, Fungal Eukaryotic Cells Fungal Proteins/chemistry,genetics Gene Duplication Genetic Diseases, Inborn Genome, Fungal Humans Introns Protein Structure, Tertiary Schizosaccharomyces/genetics Sequence Analysis, DNA
Chemicals
DNA, Fungal Fungal Proteins
Authors & Affiliations
135 authors, click to expand affiliations / ORCID
Wood V
The Wellcome Trust Sanger Institute, The Wellcome Trust Genome Campus, Hinxton, Cambridge, UK.
Gwilliam R
Rajandream M-A
Lyne M
Lyne R
Stewart A
Sgouros J
Peat N
Hayles J
Baker S
Basham D
Bowman S
Brooks K
Brown D
Brown S
Chillingworth T
Churcher C
Collins M
Connor R
Cronin A
Davis P
Feltwell T
Fraser A
Gentles S
Goble A
Hamlin N
Harris D
Hidalgo J
Hodgson G
Holroyd S
Hornsby T
Howarth S
Huckle E J
Hunt S
Jagels K
James K
Jones L
Jones M
Leather S
McDonald S
McLean J
Mooney P
Moule S
Mungall K
Murphy L
Niblett D
Odell C
Oliver K
O'Neil S
Pearson D
Quail M A
Rabbinowitsch E
Rutherford K
Rutter S
Saunders D
Seeger K
Sharp S
Skelton J
Simmonds M
Squares R
Squares S
Stevens K
Taylor K
Taylor R G
Tivey A
Walsh S
Warren T
Whitehead S
Woodward J
Volckaert G
Aert R
Robben J
Grymonprez B
Weltjens I
Vanstreels E
Rieger M
Schäfer M
Müller-Auer S
Gabel C
Fuchs M
Düsterhöft A
Fritzc C
Holzer E
Moestl D
Hilbert H
Borzym K
Langer I
Beck A
Lehrach H
Reinhardt R
Pohl T M
Eger P
Zimmermann W
Wedler H
Wambutt R
Purnelle B
Goffeau A
Cadieu E
Dréano S
Gloux S
Lelaure V
Mottier S
Galibert F
Aves S J
Xiang Z
Hunt C
Moore K
Hurst S M
Lucas M
Rochet M
Gaillardin C
Tallada V A
Garzon A
Thode G
Daga R R
Cruzado L
Jimenez J
Sánchez M
del Rey F
Benito J
Domínguez A
Revuelta J L
Moreno S
Armstrong J
Forsburg S L
Cerutti L
Lowe T
McCombie W R
Paulsen I
Potashkin J
Shpakovski G V
Ussery D
Barrell B G
Nurse P
Cerrutti L
Article Info
Journal
Nature
Abbr.
Nature
ISSN
0028-0836
Published
2002-02-21
Pages
871-80
Language
English
Region
England
NLM ID
0410462
Subset
IM
Corrections
ErratumIn
-
CommentIn
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: product@genelibs.com