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PMID: 1185684 Published · ppublish English Journal Article

Some effects of 5-hydroxytryptamine, dopamine and noradrenaline on neurones in the submucous plexus of guinea-pig small intestine.

The Journal of physiology ·Vol. 251 ·No. 3 ·1975-10-00 ·Pages 817-32

Hirst GD, Silinsky EM

Abstract

1. Responses to the iontophoretic application of 5-hydroxytryptamine (5-HT), dopamine and noradrenaline were examined in neurones of the submucous plexus of guinea-pig small intestine. 2. Every neurone was excited by 5-HT. 3. In a proportion of cells, dopamine or noradrenaline caused an increase in membrane potential. This response was only observed in cells which received in inhibitory innervation. The responses closely resembled inhibitory synaptic potentials evoked by transmural stimulation. 4. Both inhibitory synaptic potentials and inhibitory responses to dopamine and noradrenaline were blocked by methysergide. 5. It seems possible that these two catecholamines may interact with similar receptors to those activated by inhibitory transmitter.

MeSH Terms
Animals Curare/pharmacology Dopamine/pharmacology Guinea Pigs In Vitro Techniques Intestine, Small/drug effects Membrane Potentials/drug effects Methysergide/pharmacology Neural Inhibition Neurons/drug effects Norepinephrine/pharmacology Serotonin/pharmacology Submucous Plexus/drug effects Synapses/drug effects
Chemicals
Serotonin Curare Dopamine Norepinephrine Methysergide
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Hirst G D
Silinsky E M
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Article Info
Journal
The Journal of physiology
Abbr.
J Physiol
ISSN
0022-3751
DOI
10.1113/jphysiol.1975.sp011124
Published
1975-10-00
Pages
817-32
Language
English
Region
England
NLM ID
0266262
PMCID
PMC1348419
Subset
IM
External Links
PubMed source DOI: 10.1113/jphysiol.1975.sp011124 PMC Full Text View journal details
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