Pharmacokinetics in man of the N-acetylated metabolite of procainamide.

Journal of pharmacokinetics and biopharmaceutics ·Vol. 3 ·No. 4 ·1975-08-00 ·Pages 223-35

Strong JM, Dutcher JS, Lee WK, Atkinson AJ

Abstract

暂无摘要

MeSH Terms

Acetylation Computers Humans Kinetics Male Models, Biological Procainamide/analogs & derivatives,metabolism

Chemicals

Procainamide

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

Strong J M

Dutcher J S

Lee W K

Atkinson A J

References (15)

15 references, click to expand

Clearance and biologic half-life as indices of intrinsic hepatic metabolism.
J Pharmacol Exp Ther. 1974 Oct;191(1):17-24 PMID: 4423599
Procainamide dosage schedules, plasma concentrations, and clinical effects.
JAMA. 1971 Mar 1;215(9):1454-60 PMID: 5107621
Acetylation of procaine amide in man. A preliminary communication.
Eur J Clin Pharmacol. 1975;8(1):79-81 PMID: 1233205
N-acetylprocainamide: an active metabolite of procainamide.
Proc Soc Exp Biol Med. 1974 Jun;146(2):358-63 PMID: 4834444
Studies on the metabolism of para-aminobenzoic acid.
J Pharmacol Exp Ther. 1951 Jun;102(2):98-102 PMID: 14841593
Metabolism of procainamide in rhesus monkey and man.
Clin Pharmacol Ther. 1972 May-Jun;13(3):366-71 PMID: 4623713
Metabolic oxidation on aliphatic basic nitrogen atoms and their -carbon atoms--some unifying principles.
J Pharm Pharmacol. 1971 Oct;23(10):809-12 PMID: 4399924
Antiarrhythmic potency of N-acetylprocainamide.
Clin Pharmacol Ther. 1975 Feb;17(2):134-40 PMID: 1122675
Absorption, excretion, and biotransformation of procainamide-C 14 in the dog and rhesus monkey.
Arzneimittelforschung. 1971 Jul;21(7):948-51 PMID: 4998538
The fate of procaine in man following its intravenous administration and methods for the estimation of procaine and diethylaminoethanol.
J Pharmacol Exp Ther. 1948 Dec;94(4):359-66 PMID: 18105653
The physiological disposition and cardiac effects of procaine amide.
J Pharmacol Exp Ther. 1951 May;102(1):5-15 PMID: 14832740
Concept of a volume of distribution and possible errors in evaluation of this parameter.
J Pharm Sci. 1968 Jan;57(1):128-33 PMID: 5652112
Studies in para-aminohippuric acid synthesis in the human: its application as a liver function test.
J Clin Invest. 1950 Aug;29(8):1014-20 PMID: 15436870
Acetylation of procaine amide in man studied with a new gas chromatographic method.
Br J Clin Pharmacol. 1974 Dec;1(6):467-75 PMID: 22454932
Effects of N-acetylprocainamide as compared with procainamide in isolated rat atria.
Eur J Pharmacol. 1975 Aug;33(1):47-52 PMID: 1175691

Article Info

Journal

Journal of pharmacokinetics and biopharmaceutics

Abbr.

J Pharmacokinet Biopharm

ISSN

0090-466X

DOI

10.1007/BF01066919

Published

1975-08-00

Pages

223-35

Language

English

Region

United States

NLM ID

0357115

Subset

External Links

PubMed source DOI: 10.1007/BF01066919

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Pharmacokinetics in man of the N-acetylated metabolite of procainamide.

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