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PMID: 11832207 Published · ppublish English Journal Article Review

The role of PML in tumor suppression.

Cell ·Vol. 108 ·No. 2 ·2002-01-25 ·Pages 165-70

Salomoni P, Pandolfi PP

Abstract

The PML gene, involved in the t(15;17) chromosomal translocation of acute promyelocytic leukemia (APL), encodes a protein which localizes to the PML-nuclear body, a subnuclear macromolecular structure. PML controls apoptosis, cell proliferation, and senescence. Here, we review the current understanding of its role in tumor suppression.

MeSH Terms
Adaptor Proteins, Signal Transducing Animals Apoptosis/physiology Carrier Proteins/metabolism Cell Division Cell Transformation, Neoplastic Cellular Senescence Co-Repressor Proteins Genes, Tumor Suppressor/physiology Humans Intracellular Signaling Peptides and Proteins Molecular Chaperones Neoplasm Proteins/genetics,metabolism,physiology Neoplasms/genetics,physiopathology Nuclear Proteins/genetics,metabolism Oncogene Proteins, Fusion/genetics,metabolism Promyelocytic Leukemia Protein Receptors, Retinoic Acid/genetics,metabolism Retinoic Acid Receptor alpha Transcription Factors/genetics,metabolism,physiology Tumor Suppressor Protein p53/metabolism Tumor Suppressor Proteins
Chemicals
Adaptor Proteins, Signal Transducing Carrier Proteins Co-Repressor Proteins DAXX protein, human Intracellular Signaling Peptides and Proteins Molecular Chaperones Neoplasm Proteins Nuclear Proteins Oncogene Proteins, Fusion Promyelocytic Leukemia Protein RARA protein, human Receptors, Retinoic Acid Retinoic Acid Receptor alpha Transcription Factors Tumor Suppressor Protein p53 Tumor Suppressor Proteins PML protein, human
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Salomoni Paolo
Molecular Biology Program and Department of Pathology, Sloan-Kettering Institute, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA.
Pandolfi Pier Paolo
Article Info
Journal
Cell
Abbr.
Cell
ISSN
0092-8674
Published
2002-01-25
Pages
165-70
Language
English
Region
United States
NLM ID
0413066
Subset
IM
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