Neurogenesis in adult primate neocortex: an evaluation of the evidence.

Nature reviews. Neuroscience ·Vol. 3 ·No. 1 ·2002-01-00 ·Pages 65-71

Rakic P

Abstract

Reports of continuous genesis and turnover of neurons in the adult primate association neocortex--the site of the highest cognitive functions--have generated great excitement. Here, I review the available evidence, and question the scientific basis of this claim.

MeSH Terms

Animals Antimetabolites/metabolism Biomarkers Bromodeoxyuridine/metabolism Cell Cycle/physiology DNA/metabolism Macaca Models, Neurological Neocortex/cytology,physiology Neuroglia/cytology,physiology Neurons/cytology,physiology Nucleotides/metabolism

Chemicals

Antimetabolites Biomarkers Nucleotides DNA Bromodeoxyuridine

Authors & Affiliations

1 authors, click to expand affiliations / ORCID

Rakic Pasko

Pasko Rakic is at the Department of Neurobiology, Yale University School of Medicine, New Haven, Connecticut 06520, USA. pasko.rakic@yale.edu

Article Info

Journal

Nature reviews. Neuroscience

Abbr.

Nat Rev Neurosci

ISSN

1471-003X

DOI

10.1038/nrn700

pasko.rakic@yale.edu

Published

2002-01-00

Pages

65-71

Language

English

Region

England

NLM ID

100962781

Subset

External Links

PubMed source DOI: 10.1038/nrn700 View journal details

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Neurogenesis in adult primate neocortex: an evaluation of the evidence.

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