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PMID: 11821956 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

E2Fs up-regulate expression of genes involved in DNA replication, DNA repair and mitosis.

Oncogene ·Vol. 21 ·No. 3 ·2002-01-17 ·Pages 437-46

Polager S, Kalma Y, Berkovich E, Ginsberg D

Abstract

The E2F family of transcription factors plays a pivotal role in the regulation of cell proliferation in higher eukaryotes. We used DNA microarrays and cell lines containing either inducible E2F-1 or inducible E2F-3 to identify novel E2F target genes. Our data indicate that E2F up-regulates the expression of genes not previously described as E2F target genes. A number of these E2F-regulated genes are involved in DNA replication, DNA repair and mitosis. These results suggest that E2F affects cell cycle progression both at S phase and during mitosis. Furthermore, our findings indicate that E2F-dependent gene activation may contribute to the cellular response to DNA damage.

MeSH Terms
Animals Blotting, Western Cell Cycle/genetics Cell Cycle Proteins Cells, Cultured DNA Repair/genetics DNA Replication/genetics DNA-Binding Proteins E2F Transcription Factors E2F1 Transcription Factor E2F3 Transcription Factor Fibroblasts Flow Cytometry Gene Expression Profiling Mitosis/genetics MutS Homolog 2 Protein Oligonucleotide Array Sequence Analysis Promoter Regions, Genetic/genetics Proto-Oncogene Proteins/genetics RNA, Messenger/genetics,metabolism Rats Reverse Transcriptase Polymerase Chain Reaction Transcription Factors/metabolism Up-Regulation
Chemicals
Cell Cycle Proteins DNA-Binding Proteins E2F Transcription Factors E2F1 Transcription Factor E2F3 Transcription Factor E2f1 protein, rat Proto-Oncogene Proteins RNA, Messenger Transcription Factors Msh2 protein, rat MutS Homolog 2 Protein
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Polager Shirley
Department of Molecular Cell Biology, The Weizmann Institute of Science, Rehovot 76100, Israel.
Kalma Yael
Berkovich Eli
Ginsberg Doron
Article Info
Journal
Oncogene
Abbr.
Oncogene
ISSN
0950-9232
DOI
10.1038/sj.onc.1205102
Published
2002-01-17
Pages
437-46
Language
English
Region
England
NLM ID
8711562
Subset
IM
External Links
PubMed source DOI: 10.1038/sj.onc.1205102 View journal details
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