Home LiteratureArticle Details
PMID: 11819343 Published · ppublish English Journal Article

Inflammatory bowel disease: definition, epidemiology, etiologic aspects, and immunogenetic studies.

World journal of gastroenterology ·Vol. 4 ·No. 5 ·1998-10-00 ·Pages 446-458

Xia B, Crusius J, Meuwissen S, Pe?a A

Abstract

暂无摘要

Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Xia Bing
Crusius JBA
Meuwissen SGM
Pe?a AS
References (208)
208 references, click to expand
  1. Evidence of genetic heterogeneity in IBD: 1. The interleukin-1 receptor antagonist in the predisposition to suffer from ulcerative colitis.
    Eur J Gastroenterol Hepatol. 1996 Feb;8(2):105-10 PMID: 8723412
  2. Molecularly defined HLA-DR2 alleles in ulcerative colitis and an antineutrophil cytoplasmic antibody-positive subgroup.
    Gastroenterology. 1995 Feb;108(2):423-7 PMID: 7835583
  3. Susceptibility locus for inflammatory bowel disease on chromosome 16 has a role in Crohn's disease, but not in ulcerative colitis.
    Hum Mol Genet. 1996 Oct;5(10):1679-83 PMID: 8894707
  4. Epidemiology of inflammatory bowel disease: an update.
    Scand J Gastroenterol. 1996 May;31(5):417-27 PMID: 8734336
  5. Phase II trial of copper zinc superoxide dismutase (CuZnSOD) in treatment of Crohn's disease.
    Free Radic Biol Med. 1989;7(2):145-9 PMID: 2680784
  6. Restriction fragment length polymorphism analysis of T-cell receptor genes in inflammatory bowel disease.
    Scand J Gastroenterol. 1989 Apr;24(3):381-4 PMID: 2567531
  7. Possible role of mycobacteria in inflammatory bowel disease. II. Mycobacterial antibodies in Crohn's disease.
    Dig Dis Sci. 1984 Dec;29(12):1080-5 PMID: 6437775
  8. Intercellular adhesion molecule 1 gene associations with immunologic subsets of inflammatory bowel disease.
    Gastroenterology. 1995 Aug;109(2):440-8 PMID: 7615193
  9. Contribution of genes of the major histocompatibility complex to susceptibility and disease phenotype in inflammatory bowel disease.
    Lancet. 1996 May 4;347(9010):1212-7 PMID: 8622450
  10. Crohn's disease (regional enteritis) of the large intestine and its distinction from ulcerative colitis.
    Gut. 1960 Jun;1:87-105 PMID: 14417801
  11. Letter: HL-A antigens in inflammatory bowel disease.
    Lancet. 1974 Mar 30;1(7857):574-5 PMID: 4132028
  12. The incidence of Crohn's disease in northern Norway from 1983 to 1986. Northern Norway Gastroenterology Society.
    Scand J Gastroenterol. 1989 Dec;24(10):1265-70 PMID: 2690317
  13. Regional enteritis and HLA concordance in multiple siblings.
    Dig Dis Sci. 1982 Apr;27(4):330-2 PMID: 7067585
  14. Detection of a C-insertion polymorphism within the human tumor necrosis factor alpha (TNFA) gene.
    Hum Genet. 1995 Oct;96(4):493 PMID: 7557979
  15. Crohn's disease after in-utero measles virus exposure.
    Lancet. 1996 Aug 24;348(9026):515-7 PMID: 8757154
  16. HLA class II genes in primary sclerosing cholangitis and chronic inflammatory bowel disease: no HLA-DRw52a association in Swedish patients with sclerosing cholangitis.
    Gut. 1992 Jul;33(7):942-6 PMID: 1644334
  17. HLA DR4 is a marker for rapid disease progression in primary sclerosing cholangitis.
    Gastroenterology. 1994 Jan;106(1):160-7 PMID: 8276178
  18. Plasma and tissue interleukin-2 receptor levels in inflammatory bowel disease.
    Clin Exp Immunol. 1990 Oct;82(1):75-80 PMID: 2208797
  19. The epidemiology of inflammatory bowel disease: a large, population-based study in Sweden.
    Gastroenterology. 1991 Feb;100(2):350-8 PMID: 1985033
  20. Immunoregulatory properties of IL-13 in patients with inflammatory bowel disease; comparison with IL-4 and IL-10.
    Clin Exp Immunol. 1996 Jun;104(3):483-90 PMID: 9099934
  21. Familial incidence of Crohn's disease in The Netherlands and a review of the literature.
    Gastroenterology. 1984 Mar;86(3):449-52 PMID: 6693011
  22. An epidemiologic and demographic study of inflammatory bowel disease in black patients.
    Am J Dig Dis. 1974 Feb;19(2):156-60 PMID: 4811170
  23. Mycobacterium paratuberculosis in intestinal tissue from patients with Crohn's disease demonstrated by a nested primer polymerase chain reaction.
    Scand J Gastroenterol. 1994 Oct;29(10):923-9 PMID: 7839099
  24. Absence of measles virus in Crohn's disease.
    Lancet. 1995 Jan 21;345(8943):199 PMID: 7741861
  25. Interleukin-10-deficient mice develop chronic enterocolitis.
    Cell. 1993 Oct 22;75(2):263-74 PMID: 8402911
  26. In vitro studies of ulcerative colitis. I. Reactions of patients' serum with human fetal colon cells in tissue cultures.
    J Exp Med. 1963 May 1;117:705-16 PMID: 14015587
  27. Inflammatory bowel disease and tobacco smoke--a case-control study.
    Gut. 1990 Dec;31(12):1377-81 PMID: 2265777
  28. Genes for the tumor necrosis factors alpha and beta are linked to the human major histocompatibility complex.
    Proc Natl Acad Sci U S A. 1986 Nov;83(22):8699-702 PMID: 3464978
  29. Incidence of inflammatory bowel disease in Italy: a nationwide population-based study. Gruppo Italiano per lo Studio del Colon e del Retto (GISC)
    Int J Epidemiol. 1996 Oct;25(5):1044-52 PMID: 8921493
  30. Ulcerative colitis in the Jewish population of southern Israel 1961-1985: epidemiological and clinical study.
    Gut. 1987 Dec;28(12):1630-6 PMID: 3428691
  31. Increased intestinal permeability in patients with Crohn's disease and their relatives. A possible etiologic factor.
    Ann Intern Med. 1986 Dec;105(6):883-5 PMID: 3777713
  32. Gene and haplotype frequencies of HLA antigens in 269 patients with Crohn's disease.
    Scand J Gastroenterol. 1990 Oct;25(10):981-5 PMID: 2263885
  33. Relationship between ANCA and clinical activity in inflammatory bowel disease: variation in prevalence of ANCA and evidence of heterogeneity.
    J Autoimmun. 1997 Apr;10(2):175-80 PMID: 9185879
  34. Incidence of ulcerative colitis and indeterminate colitis in four counties of southeastern Norway, 1990-93. A prospective population-based study. The Inflammatory Bowel South-Eastern Norway (IBSEN) Study Group of Gastroenterologists.
    Scand J Gastroenterol. 1996 Apr;31(4):362-6 PMID: 8726304
  35. Incidence of Crohn's disease in four counties in southeastern Norway, 1990-93. A prospective population-based study. The Inflammatory Bowel South-Eastern Norway (IBSEN) Study Group of Gastroenterologists.
    Scand J Gastroenterol. 1996 Apr;31(4):355-61 PMID: 8726303
  36. Polymorphism in human IL-1 receptor antagonist gene intron 2 is caused by variable numbers of an 86-bp tandem repeat.
    Hum Genet. 1993 May;91(4):403-4 PMID: 8500797
  37. Plasma interleukin-2 and a soluble/shed interleukin-2 receptor in serum of patients with Crohn's disease. Effect of cyclosporin.
    Gut. 1990 Jul;31(7):795-9 PMID: 2370014
  38. Autoimmunity to cytoskeletal protein tropomyosin. A clue to the pathogenetic mechanism for ulcerative colitis.
    J Immunol. 1993 Mar 15;150(6):2487-93 PMID: 8450225
  39. Analysis of genes within the HLA region affecting susceptibility to ulcerative colitis.
    Hum Immunol. 1993 Feb;36(2):112-8 PMID: 8096500
  40. Evidence for genetic heterogeneity in inflammatory bowel disease (IBD); HLA genes in the predisposition to suffer from ulcerative colitis (UC) and Crohn's disease (CD).
    Clin Exp Immunol. 1997 Jul;109(1):175-9 PMID: 9218841
  41. Polymorphic tandem repeat region in interleukin-1 alpha intron 6.
    Hum Genet. 1993 Mar;91(1):85-6 PMID: 8095919
  42. HLA antigen frequencies in familial Crohn's disease (CD).
    Beitr Infusionsther. 1990;26:283-6 PMID: 1703853
  43. Low degree of DNA polymorphism in the HLA-linked lymphotoxin (tumour necrosis factor beta) gene.
    Scand J Immunol. 1988 Sep;28(3):313-6 PMID: 2904171
  44. Histocompatibility antigens in patients with inflammatory-bowel disease.
    Lancet. 1974 Jan 26;1(7848):113-5 PMID: 4130311
  45. Familial prevalence of inflammatory bowel disease in relatives of patients with Crohn's disease.
    Br Med J. 1980 Jan 12;280(6207):84 PMID: 7353132
  46. Activation of peripheral blood and intestinal lamina propria lymphocytes in Crohn's disease. In vivo state of activation and in vitro response to stimulation as defined by the expression of early activation antigens.
    Gut. 1987 Jun;28(6):745-53 PMID: 3040543
  47. Histocompatibility antigens (HLA-A, B) and ulcerative colitis in a Greek population.
    Digestion. 1986;33(4):229-32 PMID: 3456944
  48. Mapping of a susceptibility locus for Crohn's disease on chromosome 16.
    Nature. 1996 Feb 29;379(6568):821-3 PMID: 8587604
  49. Epidemiology of inflammatory bowel disease in the Province of Granada, Spain: a retrospective study from 1979 to 1988.
    Gut. 1993 Sep;34(9):1207-9 PMID: 8406155
  50. Epidemiology of Crohn's disease in western Norway. Study group of Inflammatory Bowel Disease in Western Norway.
    Scand J Gastroenterol. 1989 Dec;24(10):1271-5 PMID: 2602908
  51. Cytokine gene polymorphisms in inflammatory bowel disease.
    Gut. 1996 Nov;39(5):705-10 PMID: 9014770
  52. T-cell transfer and cytokine/TCR gene deletion models in the study of inflammatory bowel disease.
    APMIS. 1997 Sep;105(9):655-62 PMID: 9350208
  53. HL-A frequencies in Crohn's disease and ulcerative colitis.
    Tissue Antigens. 1976 Mar;7(3):145-50 PMID: 936199
  54. Persistent measles virus infection of the intestine: confirmation by immunogold electron microscopy.
    Gut. 1995 Apr;36(4):564-9 PMID: 7737565
  55. Epidemiology of Crohn's disease in Regio Leiden, The Netherlands. A population study from 1979 to 1983.
    Gastroenterology. 1987 Nov;93(5):966-74 PMID: 3498661
  56. Clonal analysis of human cytotoxic T lymphocytes: T4+ and T8+ effector T cells recognize products of different major histocompatibility complex regions.
    Proc Natl Acad Sci U S A. 1982 Jul;79(14):4395-9 PMID: 6981813
  57. Mucosal imbalance of IL-1 and IL-1 receptor antagonist in inflammatory bowel disease. A novel mechanism of chronic intestinal inflammation.
    J Immunol. 1995 Mar 1;154(5):2434-40 PMID: 7868909
  58. Immunoregulatory function of lamina propria T cells in Crohn's disease.
    Gastroenterology. 1985 May;88(5 Pt 1):1143-50 PMID: 2858428
  59. An immunohistological study of CD4+ lymphocyte subsets within inflammatory lesions with special reference to rheumatoid arthritis and inflammatory bowel disease.
    Immunology. 1988 Nov;65(3):457-63 PMID: 2974833
  60. Incidence of Crohn's disease at Groote Schuur Hospital during 1970-1974.
    S Afr Med J. 1975 Apr 19;49(17):693-7 PMID: 1135713
  61. Is measles vaccination a risk factor for inflammatory bowel disease?
    Lancet. 1995 Apr 29;345(8957):1071-4 PMID: 7715338
  62. HLA antigens in inflammatory bowel disease.
    Tissue Antigens. 1978 Feb;11(2):147-52 PMID: 77060
  63. HLA antigens and ulcerative colitis in Japan.
    Digestion. 1977;15(4):286-94 PMID: 140831
  64. Glycoprotein composition of colonic mucosa. Specific alterations in ulcerative colitis.
    Gastroenterology. 1984 Nov;87(5):991-8 PMID: 6090262
  65. Histocompatibility antigens and other genetic markers in ankylosing spondylitis and inflammatory bowel diseases.
    J Immunogenet. 1977 Jun;4(3):167-75 PMID: 901632
  66. Antimycobacterial therapy in Crohn's disease: results of a controlled, double-blind trial with a multiple antibiotic regimen.
    Am J Gastroenterol. 1994 Apr;89(4):513-8 PMID: 8147352
  67. An HLA study on 149 Japanese patients with Crohn's disease.
    Gastroenterol Jpn. 1992 Aug;27(4):496-501 PMID: 1526431
  68. Genetic and immunological markers in pouchitis.
    Eur J Gastroenterol Hepatol. 1996 Oct;8(10):951-5 PMID: 8930557
  69. Ulcerative colitis and HLA phenotype.
    Gut. 1985 Sep;26(9):952-4 PMID: 3861473
  70. The epidemiology of inflammatory bowel disease in Cape Town 1980-1984.
    S Afr Med J. 1986 Jul 5;70(1):10-5 PMID: 3726680
  71. Incidence of inflammatory bowel disease across Europe: is there a difference between north and south? Results of the European Collaborative Study on Inflammatory Bowel Disease (EC-IBD).
    Gut. 1996 Nov;39(5):690-7 PMID: 9014768
  72. Ulcerative colitis-like disease in mice with a disrupted interleukin-2 gene.
    Cell. 1993 Oct 22;75(2):253-61 PMID: 8402910
  73. T-cell activation in Crohn's disease. Increased levels of soluble interleukin-2 receptor in serum and in supernatants of stimulated peripheral blood mononuclear cells.
    Gastroenterology. 1990 Mar;98(3):639-46 PMID: 2298368
  74. Smoking and inflammatory bowel disease. A case control study.
    Gut. 1988 Mar;29(3):352-7 PMID: 3356367
  75. An epidemiologic study of inflammatory bowel disease in Rochester, New York. Hospital incidence.
    Gastroenterology. 1990 Jan;98(1):104-10 PMID: 2293567
  76. Single base polymorphism in the human tumour necrosis factor alpha (TNF alpha) gene detectable by NcoI restriction of PCR product.
    Hum Mol Genet. 1992 Aug;1(5):353 PMID: 1363876
  77. Genetics versus environment in inflammatory bowel disease: results of a British twin study.
    BMJ. 1996 Jan 13;312(7023):95-6 PMID: 8555939
  78. B cell alloantigens in Sicilian patients with Crohn's disease.
    Tissue Antigens. 1983 Feb;21(2):170-2 PMID: 6601867
  79. A TaqI polymorphism in the human interleukin-1 beta (IL-1 beta) gene correlates with IL-1 beta secretion in vitro.
    Eur J Clin Invest. 1992 Jun;22(6):396-402 PMID: 1353022
  80. A new restriction fragment length polymorphism of the human TNF-B gene detected by AspHI digest.
    Eur J Immunogenet. 1992 Dec;19(6):425-30 PMID: 1362079
  81. Inflammatory bowel disease: an immunity-mediated condition triggered by bacterial infection with Helicobacter hepaticus.
    Infect Immun. 1997 Aug;65(8):3126-31 PMID: 9234764
  82. Immunological studies in Crohn's disease. I. Association with HLA systems in the Japanese.
    J Clin Lab Immunol. 1984 Jun;14(2):99-102 PMID: 6611420
  83. Incidence and prevalence of ulcerative colitis in Copenhagen county from 1962 to 1987.
    Scand J Gastroenterol. 1991 Dec;26(12):1247-56 PMID: 1763295
  84. Familial Crohn's disease in multiple siblings: no linkage to the HLA system.
    Gastroenterol Clin Biol. 1989 Aug-Sep;13(8-9):676-8 PMID: 2806803
  85. Differences in immunophenotyping of mucosal lymphocytes between ulcerative colitis and Crohn's disease.
    Korean J Intern Med. 1997 Jan;12(1):7-15 PMID: 9159031
  86. Overlap in the spectrum of non-specific inflammatory bowel disease--'colitis indeterminate'.
    J Clin Pathol. 1978 Jun;31(6):567-77 PMID: 670413
  87. Incidence and prevalence of Crohn's disease in the county of Copenhagen, 1962-87: a sixfold increase in incidence.
    Scand J Gastroenterol. 1992 Jul;27(7):609-14 PMID: 1641589
  88. The expanding universe of T-cell subsets: Th1, Th2 and more.
    Immunol Today. 1996 Mar;17(3):138-46 PMID: 8820272
  89. The use of antimycobacterial agents in Crohn's disease.
    J Clin Gastroenterol. 1992 Jul;15(1):5-7 PMID: 1323594
  90. Intestinal permeability in patients with Crohn's disease and their first degree relatives.
    Gut. 1992 Mar;33(3):320-3 PMID: 1568650
  91. The incidence of ulcerative colitis in Northern Norway from 1983 to 1986. The Northern Norwegian Gastroenterology Society.
    Scand J Gastroenterol. 1990 Sep;25(9):890-6 PMID: 2218395
  92. Lessons from genetic models of inflammatory bowel disease.
    Acta Gastroenterol Belg. 1997 Apr-Jun;60(2):163-5 PMID: 9260328
  93. Helicobacter bilis-induced inflammatory bowel disease in scid mice with defined flora.
    Infect Immun. 1997 Nov;65(11):4858-64 PMID: 9353076
  94. Tumor necrosis factor microsatellites define a Crohn's disease-associated haplotype on chromosome 6.
    Gastroenterology. 1996 Apr;110(4):1053-60 PMID: 8612993
  95. Distinct relationship between HLA-DR genes and intractability of ulcerative colitis.
    Am J Gastroenterol. 1994 Nov;89(11):1957-62 PMID: 7942717
  96. Role of reactive oxygen metabolites in experimental colitis.
    Gut. 1990 Jul;31(7):786-90 PMID: 2164491
  97. HLA antigens in inflammatory bowel disease.
    Tohoku J Exp Med. 1980 Aug;131(4):381-5 PMID: 7466804
  98. Polymorphic structure of the tumor necrosis factor (TNF) locus: an NcoI polymorphism in the first intron of the human TNF-beta gene correlates with a variant amino acid in position 26 and a reduced level of TNF-beta production.
    J Exp Med. 1991 Jan 1;173(1):209-19 PMID: 1670638
  99. HLA antigens in ankylosing spondylitis associated with Crohn's disease. Increased frequency of the HLA phenotype B27,B44.
    J Rheumatol. 1988 Nov;15(11):1658-61 PMID: 3266250
  100. Evidence of persistent measles virus infection in Crohn's disease.
    J Med Virol. 1993 Apr;39(4):345-53 PMID: 8492105
  101. Agents capable of eliminating reactive oxygen species. Catalase, WR-2721, or Cu(II)2(3,5-DIPS)4 decrease experimental colitis.
    Dig Dis Sci. 1992 Dec;37(12):1866-73 PMID: 1335406
  102. Novel compound tetra-, dinucleotide microsatellite polymorphism in the tumor necrosis factor/lymphotoxin locus.
    Clin Diagn Lab Immunol. 1997 Jan;4(1):79-84 PMID: 9008286
  103. Highly informative typing of the human TNF locus using six adjacent polymorphic markers.
    Genomics. 1993 Apr;16(1):180-6 PMID: 8486354
  104. Nonspecific inflammatory bowel disease and smoking.
    Am J Epidemiol. 1987 Mar;125(3):445-52 PMID: 3812450
  105. Measles virus in Crohn's disease.
    Lancet. 1995 Mar 11;345(8950):660 PMID: 7534857
  106. HLA class II gene frequencies in Crohn's disease: a population based analysis in Germany.
    Gut. 1996 Apr;38(4):538-42 PMID: 8707084
  107. HL-A 27 in Crohn's disease.
    Ann Rheum Dis. 1974 Sep;33(5):422-4 PMID: 4417403
  108. Genetic polymorphism of human interleukin-1 alpha.
    Eur J Immunol. 1993 Jun;23(6):1240-5 PMID: 8099012
  109. Are HLA-DR or TAP genes genetic markers of severity in ulcerative colitis?
    J Autoimmun. 1996 Dec;9(6):777-84 PMID: 9115580
  110. Differential expression of CD25 (interleukin-2 receptor) on lamina propria T cells and macrophages in the intestinal lesions in Crohn's disease and ulcerative colitis.
    Gut. 1990 Dec;31(12):1365-70 PMID: 2101599
  111. Frequency of inflammatory bowel disease in offspring of couples both presenting with inflammatory bowel disease.
    Gastroenterology. 1991 Jun;100(6):1638-43 PMID: 2019369
  112. Intestinal permeability of 51Cr-labelled ethylenediaminetetraacetic acid in patients with Crohn's disease and their healthy relatives.
    Scand J Gastroenterol. 1989 Oct;24(8):993-8 PMID: 2512633
  113. Mycobacteria in the intestine of Japanese patients with inflammatory bowel disease.
    Am J Gastroenterol. 1995 Jan;90(1):76-80 PMID: 7801954
  114. Neutralization of endogenous IL-1 receptor antagonist exacerbates and prolongs inflammation in rabbit immune colitis.
    J Clin Invest. 1994 Jul;94(1):449-53 PMID: 8040288
  115. Positive and negative associations of distinct HLA-DR2 subtypes with ulcerative colitis (UC).
    Clin Exp Immunol. 1997 Jun;108(3):392-5 PMID: 9182881
  116. Crohn's disease in the Japanese is associated with the HLA-DRw53.
    Exp Clin Immunogenet. 1990;7(2):101-8 PMID: 2322470
  117. Evidence that activated mucosal T cells play a role in the pathogenesis of enteropathy in human small intestine.
    J Exp Med. 1988 Apr 1;167(4):1341-9 PMID: 2965735
  118. Characteristics of an unclassified Mycobacterium species isolated from patients with Crohn's disease.
    J Clin Microbiol. 1984 Nov;20(5):966-71 PMID: 6511878
  119. Intestinal permeability in patients with Crohn's disease and ulcerative colitis and their first degree relatives.
    Gut. 1994 Jan;35(1):68-72 PMID: 8307453
  120. Definition of a lamina propria T cell responsive state. Enhanced cytokine responsiveness of T cells stimulated through the CD2 pathway.
    J Immunol. 1995 Jan 15;154(2):664-75 PMID: 7529282
  121. Distinct associations of HLA class II genes with inflammatory bowel disease.
    Gastroenterology. 1993 Mar;104(3):741-8 PMID: 8440433
  122. HLA-DR, DQ and T cell antigen receptor constant beta genes in Japanese patients with ulcerative colitis.
    Clin Exp Immunol. 1990 Jun;80(3):400-3 PMID: 1973647
  123. Oral tolerance: immune mechanisms and treatment of autoimmune diseases.
    Immunol Today. 1997 Jul;18(7):335-43 PMID: 9238837
  124. Ulcerative colitis and Crohn's disease in an unselected population of monozygotic and dizygotic twins. A study of heritability and the influence of smoking.
    Gut. 1988 Jul;29(7):990-6 PMID: 3396969
  125. Activation and signaling status of human lamina propria T lymphocytes.
    Gastroenterology. 1991 Dec;101(6):1529-36 PMID: 1955119
  126. Epithelial deposits of immunoglobulin G1 and activated complement colocalise with the M(r) 40 kD putative autoantigen in ulcerative colitis.
    Gut. 1993 May;34(5):650-7 PMID: 8504966
  127. Crohn's disease in Ashkenazi Jews.
    Gastroenterology. 1990 Jul;99(1):286-7 PMID: 2344938
  128. Lack of an association between polymorphisms of the T-cell receptor alpha-chain and ulcerative colitis.
    Gastroenterology. 1989 Nov;97(5):1115-20 PMID: 2571544
  129. Risk of ulcerative colitis among former and current cigarette smokers.
    N Engl J Med. 1987 Mar 19;316(12):707-10 PMID: 3821808
  130. Spontaneous development of inflammatory bowel disease in T cell receptor mutant mice.
    Cell. 1993 Oct 22;75(2):274-82 PMID: 8104709
  131. Geographic origins of Jewish patients with inflammatory bowel disease.
    Gastroenterology. 1989 Oct;97(4):900-4 PMID: 2777043
  132. An increased risk of Crohn's disease in individuals who inherit the HLA class II DRB3*0301 allele.
    Proc Natl Acad Sci U S A. 1996 May 14;93(10):5094-8 PMID: 8643533
  133. Activation of human T lymphocyte subsets: helper and suppressor/cytotoxic T cells recognize and respond to distinct histocompatibility antigens.
    J Immunol. 1981 Nov;127(5):2124-9 PMID: 6457863
  134. A distinct subset of antineutrophil cytoplasmic antibodies is associated with inflammatory bowel disease.
    J Allergy Clin Immunol. 1990 Aug;86(2):202-10 PMID: 2200820
  135. Circulating antibodies against human colonic extract enriched with a 40 kDa protein in patients with ulcerative colitis.
    Gut. 1990 Sep;31(9):1016-20 PMID: 2210446
  136. Allelic polymorphism in IL-1 beta and IL-1 receptor antagonist (IL-1Ra) genes in inflammatory bowel disease.
    Clin Exp Immunol. 1995 Nov;102(2):379-83 PMID: 7586694
  137. Imbalance of the interleukin 1 system in colonic mucosa--association with intestinal inflammation and interleukin 1 receptor antagonist [corrected] genotype 2.
    Gut. 1997 Nov;41(5):651-7 PMID: 9414973
  138. Single base polymorphism at -511 in the human interleukin-1 beta gene (IL1 beta).
    Hum Mol Genet. 1992 Sep;1(6):450 PMID: 1301918
  139. HLA-DRB1*1502 allele, subtype of DR15, is associated with susceptibility to ulcerative colitis and its progression.
    Dig Dis Sci. 1995 Apr;40(4):814-8 PMID: 7720475
  140. Inflammatory bowel disease in the Bedouin Arabs of southern Israel: rarity of diagnosis and clinical features.
    Gut. 1991 Sep;32(9):1024-6 PMID: 1916484
  141. Detection of immunoreactive antigen, with a monoclonal antibody to measles virus, in tissue from a patient with Crohn's disease.
    J Gastroenterol. 1995 Feb;30(1):28-33 PMID: 7719411
  142. Controlled trial of antimycobacterial therapy in Crohn's disease. Clofazimine versus placebo.
    Dig Dis Sci. 1991 Apr;36(4):449-53 PMID: 2007362
  143. Ulcerative colitis in Zagreb, Yugoslavia: incidence and prevalence 1980-1989.
    Int J Epidemiol. 1991 Dec;20(4):1043-7 PMID: 1800402
  144. Analysis of the contribution of HLA genes to genetic predisposition in inflammatory bowel disease.
    Am J Hum Genet. 1996 Jul;59(1):226-33 PMID: 8659528
  145. Measles virus serology in Crohn's disease.
    Gut. 1997 Jul;41(1):66-9 PMID: 9274474
  146. Association of the human lymphocyte-DR2 antigen with Japanese ulcerative colitis.
    Gastroenterology. 1982 Mar;82(3):413-8 PMID: 6947923
  147. Genetic variability in the TNF-alpha promoter is not associated with type II diabetes mellitus (NIDDM).
    Biochem Biophys Res Commun. 1995 Jun 26;211(3):833-9 PMID: 7598712
  148. Polymerase chain reaction detection of Mycobacterium paratuberculosis and Mycobacterium avium subsp silvaticum in long term cultures from Crohn's disease and control tissues.
    Gut. 1992 Sep;33(9):1209-13 PMID: 1427373
  149. Testing nicotine gum for ulcerative colitis patients. Experience with single-patient trials.
    Dig Dis Sci. 1990 Jul;35(7):827-32 PMID: 2194767
  150. A physical map of the region encompassing the human interleukin-1 alpha, interleukin-1 beta, and interleukin-1 receptor antagonist genes.
    Genomics. 1994 Jan 15;19(2):382-4 PMID: 8188271
  151. PEG-400 excretion in patients with Crohn's disease, their first-degree relatives, and healthy volunteers.
    Dig Dis Sci. 1992 May;37(5):705-8 PMID: 1563311
  152. Epidemiology of Crohn's disease in Zagreb, Yugoslavia: a ten-year prospective study.
    Int J Epidemiol. 1991 Mar;20(1):216-20 PMID: 2066223
  153. Inflammatory bowel disease mucosal biopsies have specialized lymphokine mRNA profiles.
    Inflamm Bowel Dis. 1996 Spring;2(1):16-26 PMID: 23282452
  154. The immune system in inflammatory bowel disease.
    Acta Gastroenterol Belg. 1997 Apr-Jun;60(2):156-62 PMID: 9260327
  155. Lack of association between an interleukin-1 receptor antagonist gene polymorphism and ulcerative colitis.
    Gut. 1997 May;40(5):623-7 PMID: 9203941
  156. T cell antigen receptor V gene usage. Increases in V beta 8+ T cells in Crohn's disease.
    J Clin Invest. 1990 Jun;85(6):1770-6 PMID: 1971828
  157. Is small intestinal permeability really increased in relatives of patients with Crohn's disease?
    Gastroenterology. 1993 Jun;104(6):1627-32 PMID: 8500719
  158. The genetics of Crohn disease: complex segregation analysis of a family study with 265 patients with Crohn disease and 5,387 relatives.
    Am J Med Genet. 1989 Jan;32(1):105-8 PMID: 2705471
  159. Study of the carbohydrate content of mucus glycoproteins from normal and diseased colons.
    Clin Sci (Lond). 1981 Aug;61(2):229-34 PMID: 7261546
  160. Synergistic effect of immunoregulatory cytokines on peripheral blood monocytes from patients with inflammatory bowel disease.
    Dig Dis Sci. 1997 Apr;42(4):805-12 PMID: 9125653
  161. High incidence of inflammatory bowel disease in The Netherlands: results of a prospective study. The South Limburg IBD Study Group.
    Dis Colon Rectum. 1998 Jan;41(1):33-40 PMID: 9510308
  162. Intestinal lymphocyte subpopulations in inflammatory bowel disease: an analysis by immunohistological and cell isolation techniques.
    Gut. 1984 Jan;25(1):32-40 PMID: 6228498
  163. A population-based study of inflammatory bowel disease in Florence over 15 years (1978-92).
    Scand J Gastroenterol. 1996 Sep;31(9):892-9 PMID: 8888437
  164. Investigation of inheritance of chronic inflammatory bowel diseases by complex segregation analysis.
    BMJ. 1993 Jan 2;306(6869):20-4 PMID: 8435571
  165. Two stage genome-wide search in inflammatory bowel disease provides evidence for susceptibility loci on chromosomes 3, 7 and 12.
    Nat Genet. 1996 Oct;14(2):199-202 PMID: 8841195
  166. Reciprocal IFN-gamma and TGF-beta responses regulate the occurrence of mucosal inflammation.
    Immunol Today. 1997 Feb;18(2):61-4 PMID: 9057354
  167. Linkage analyses of chromosome 6 loci, including HLA, in familial aggregations of Crohn disease. G.E.T.A.I.D.
    Am J Med Genet. 1994 Aug 15;52(2):207-13 PMID: 7802010
  168. Crohn's disease in the northeastern and northern Isles of Scotland: an epidemiological review.
    Gastroenterology. 1992 Aug;103(2):392-9 PMID: 1634058
  169. A case-control study of ulcerative colitis with relation to smoking habits and alcohol consumption in Japan.
    Am J Epidemiol. 1994 Nov 15;140(10):902-11 PMID: 7977277
  170. Circulating antiinflammatory cytokine IL-10 in patients with inflammatory bowel disease (IBD).
    Clin Exp Immunol. 1995 Jun;100(3):452-6 PMID: 7774055
  171. HLA antigen distribution and HLA haplotype segregation in Crohn's disease.
    Tissue Antigens. 1980 Jul;16(1):56-61 PMID: 6162229
  172. Cigarette smoking and quality of life in patients with inflammatory bowel disease. South Limburg IBD Study Group.
    Eur J Gastroenterol Hepatol. 1996 Nov;8(11):1075-81 PMID: 8944369
  173. Novel genetic association between ulcerative colitis and the anti-inflammatory cytokine interleukin-1 receptor antagonist.
    Gastroenterology. 1994 Mar;106(3):637-42 PMID: 8119534
  174. Colonic mucosal interleukin 1 receptor antagonist in inflammatory bowel disease.
    Digestion. 1994;55(6):368-73 PMID: 7705549
  175. Controlled trial of anti-tuberculous chemotherapy for two years in Crohn's disease.
    Gut. 1994 Mar;35(3):363-8 PMID: 8150348
  176. Role of animal models for the pathogenesis and treatment of inflammatory bowel disease.
    Scand J Gastroenterol Suppl. 1997;223:99-104 PMID: 9200314
  177. Crohn's disease in a defined population. An epidemiological study of incidence, prevalence, mortality, and secular trends in the city of Malmö, Sweden.
    Gastroenterology. 1975 Aug;69(2):342-51 PMID: 1150043
  178. Pathogenesis and immune mechanisms of chronic inflammatory bowel diseases.
    Am J Gastroenterol. 1997 Dec;92(12 Suppl):5S-11S PMID: 9395346
  179. Chronic ulcerative colitis: incidence and prevalence in a community.
    Gut. 1987 Apr;28(4):402-9 PMID: 3583067
  180. Neutralization of tumour necrosis factor (TNF) but not of IL-1 reduces inflammation in chronic dextran sulphate sodium-induced colitis in mice.
    Clin Exp Immunol. 1997 Feb;107(2):353-8 PMID: 9030875
  181. Ulcerative colitis: a genetically heterogeneous disorder defined by genetic (HLA class II) and subclinical (antineutrophil cytoplasmic antibodies) markers.
    J Clin Invest. 1993 Aug;92(2):1080-4 PMID: 8349790
  182. Crohn's disease: pathogenesis and persistent measles virus infection.
    Gastroenterology. 1995 Mar;108(3):911-6 PMID: 7875495
  183. Polymorphism of complement C3 in chronic inflammatory bowel disease. Predominance of the C3F gene in Crohn's disease.
    Acta Med Scand. 1984;215(4):375-8 PMID: 6731047
  184. Colonic mucus and mucosal glycoproteins: the key to colitis and cancer?
    Gut. 1989 Dec;30(12):1660-6 PMID: 2693227
  185. HLA-linked susceptibility and resistance genes in Crohn's disease.
    Gastroenterology. 1995 Nov;109(5):1462-7 PMID: 7557126
  186. Genetic markers may predict disease behavior in patients with ulcerative colitis.
    Gastroenterology. 1997 Jun;112(6):1845-53 PMID: 9178675
  187. Genetics of inflammatory bowel disease.
    Gut. 1994 May;35(5):696-700 PMID: 8200569
  188. T cell differentiation antigens on lymphocytes in the human intestinal lamina propria.
    J Immunol. 1992 Oct 15;149(8):2816-22 PMID: 1383328
  189. Epidemiology of proctocolitis in the region of Leiden, The Netherlands. A population study from 1979 to 1983.
    Scand J Gastroenterol. 1987 Oct;22(8):993-1002 PMID: 3685885
  190. Intestinal permeability changes in response to acetylsalicylic acid in relatives of patients with Crohn's disease.
    Gastroenterology. 1996 May;110(5):1395-403 PMID: 8613043
  191. Monozygotic twins with Crohn's disease and ulcerative colitis: a unique case report.
    Gut. 1997 Oct;41(4):557-60 PMID: 9391259
  192. A prospective epidemiologic study of Crohn's disease in Heraklion, Crete. Incidence over a 5-year period.
    Scand J Gastroenterol. 1996 Jun;31(6):599-603 PMID: 8789900
  193. Potential antiinflammatory effects of interleukin 4: suppression of human monocyte tumor necrosis factor alpha, interleukin 1, and prostaglandin E2.
    Proc Natl Acad Sci U S A. 1989 May;86(10):3803-7 PMID: 2786204
  194. Association of HLA class II genes with susceptibility to Crohn's disease.
    Gut. 1996 Jul;39(1):69-72 PMID: 8881812
  195. Transdermal nicotine for active ulcerative colitis.
    N Engl J Med. 1994 Mar 24;330(12):811-5 PMID: 8114833
  196. A polymorphic variation in a putative regulation box of the TNFA promoter region.
    Immunogenetics. 1994;39(2):150-4 PMID: 7903959
  197. Autoantibodies in human ulcerative colitis.
    J Exp Med. 1959 Nov 1;110:657-74 PMID: 13804543
  198. Transdermal nicotine as maintenance therapy for ulcerative colitis.
    N Engl J Med. 1995 Apr 13;332(15):988-92 PMID: 7885427
  199. TAP gene transporter polymorphism in inflammatory bowel diseases.
    Scand J Gastroenterol. 1997 Oct;32(10 ):1022-7 PMID: 9361175
  200. Natural history of indeterminate colitis.
    Br J Surg. 1991 Feb;78(2):179-81 PMID: 2015465
  201. Possible role of mycobacteria in inflammatory bowel disease. I. An unclassified Mycobacterium species isolated from patients with Crohn's disease.
    Dig Dis Sci. 1984 Dec;29(12):1073-9 PMID: 6499624
  202. Unidentified curved bacilli on gastric epithelium in active chronic gastritis.
    Lancet. 1983 Jun 4;1(8336):1273-5 PMID: 6134060
  203. Regional enteritis: evidence for genetic transmission by HLA typing.
    Ann Intern Med. 1980 Sep;93(3):424-7 PMID: 7436159
  204. Central MHC genes, IgA deficiency and autoimmune disease.
    Immunol Today. 1990 Aug;11(8):271-4 PMID: 2206270
  205. Cigarette smoking in Crohn's disease.
    Am J Gastroenterol. 1989 Jan;84(1):31-3 PMID: 2912028
  206. A multiplex polymerase chain reaction assay for the detection of Mycobacterium paratuberculosis DNA in Crohn's disease tissue.
    Scand J Gastroenterol. 1997 Aug;32(8):819-23 PMID: 9282975
  207. Oxidants and free radicals in inflammatory bowel disease.
    Lancet. 1994 Sep 24;344(8926):859-61 PMID: 7916405
  208. A meta-analysis of the role of smoking in inflammatory bowel disease.
    Dig Dis Sci. 1989 Dec;34(12):1841-54 PMID: 2598752
Article Info
Journal
World journal of gastroenterology
Abbr.
World J Gastroenterol
ISSN
2219-2840
DOI
10.3748/wjg.v4.i5.446
Published
1998-10-00
Pages
446-458
Language
English
Region
United States
NLM ID
100883448
PMCID
PMC4767749
External Links
PubMed source DOI: 10.3748/wjg.v4.i5.446 PMC Full Text View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: product@genelibs.com

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2