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PMID: 11802771 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

A novel immunoglobulin superfamily receptor (19A) related to CD2 is expressed on activated lymphocytes and promotes homotypic B-cell adhesion.

The Biochemical journal ·Vol. 361 ·No. Pt 3 ·2002-02-01 ·Pages 431-6

Murphy JJ, Hobby P, Vilarino-Varela J, Bishop B, Iordanidou P, Sutton BJ, Norton JD

Abstract

A novel lymphocyte-specific immunoglobulin superfamily protein (19A) has been cloned. The predicted 335-amino-acid sequence of 19A represents a Type 1 membrane protein with homology with the CD2 family of receptors. A molecular model of the two predicted extracellular immunoglobulin-like domains of 19A has been generated using the crystal structure of CD2 as a template. In isolated lymphocytes, expression of 19A is induced by various activation stimuli, and enforced expression of the 19A gene promotes homotypic cell adhesion in a B-cell-line model. Collectively these data imply that the 19A protein plays a role in regulation of lymphocyte adhesion.

MeSH Terms
Amino Acid Sequence B-Lymphocytes/cytology,metabolism Base Sequence Blotting, Northern CD2 Antigens/chemistry Cell Adhesion Cell Line Cloning, Molecular DNA, Complementary/metabolism Humans Immunoglobulins/chemistry Lymphocyte Activation Models, Molecular Molecular Sequence Data Protein Structure, Tertiary RNA/metabolism Receptors, Immunologic/biosynthesis,chemistry Sequence Homology, Amino Acid Signaling Lymphocytic Activation Molecule Family Time Factors Tissue Distribution Transfection
Chemicals
CD2 Antigens DNA, Complementary Immunoglobulins Receptors, Immunologic SLAMF7 protein, human Signaling Lymphocytic Activation Molecule Family RNA
Authors & Affiliations
7 authors, click to expand affiliations / ORCID
Murphy John J
Infection and Immunity Research Group, Division of Life Sciences, King's College London, Franklin-Wilkins Building, 150 Stamford Street, London SE1 9NN, UK. john.murphy@kcl.ac.uk
Hobby Paul
Vilarino-Varela Juan
Bishop Benjamin
Iordanidou Panagiota
Sutton Brian J
Norton John D
References (17)
17 references, click to expand
  1. Structure of a heterophilic adhesion complex between the human CD2 and CD58 (LFA-3) counterreceptors.
    Cell. 1999 Jun 11;97(6):791-803 PMID: 10380930
  2. Characterization of inhibitory and stimulatory forms of the murine natural killer cell receptor 2B4.
    Proc Natl Acad Sci U S A. 1999 Mar 30;96(7):3870-5 PMID: 10097130
  3. 2B4: an NK cell activating receptor with unique specificity and signal transduction mechanism.
    Hum Immunol. 2000 Jan;61(1):39-43 PMID: 10658976
  4. 2B4 functions as a co-receptor in human NK cell activation.
    Eur J Immunol. 2000 Mar;30(3):787-93 PMID: 10741393
  5. The CD2-subset of the Ig superfamily of cell surface molecules: receptor-ligand pairs expressed by NK cells and other immune cells.
    Semin Immunol. 2000 Apr;12(2):149-57 PMID: 10764623
  6. ID helix-loop-helix proteins in cell growth, differentiation and tumorigenesis.
    J Cell Sci. 2000 Nov;113 ( Pt 22):3897-905 PMID: 11058077
  7. Cell-type-specific early response gene expression during plasmacytoid differentiation of human B lymphocytic leukemia cells.
    Biochim Biophys Acta. 1990 Jul 30;1049(3):261-71 PMID: 2383585
  8. Mutational analysis of the epitopes recognized by anti-(rat CD2) and anti-(rat CD48) monoclonal antibodies.
    Biochem Soc Trans. 1995 Feb;23(1):188-94 PMID: 7538945
  9. A novel receptor involved in T-cell activation.
    Nature. 1995 Jul 20;376(6537):260-3 PMID: 7617038
  10. Protein fold recognition using sequence-derived predictions.
    Protein Sci. 1996 May;5(5):947-55 PMID: 8732766
  11. Soluble and membrane-bound forms of signaling lymphocytic activation molecule (SLAM) induce proliferation and Ig synthesis by activated human B lymphocytes.
    J Exp Med. 1997 Mar 17;185(6):993-1004 PMID: 9091591
  12. Gapped BLAST and PSI-BLAST: a new generation of protein database search programs.
    Nucleic Acids Res. 1997 Sep 1;25(17):3389-402 PMID: 9254694
  13. CD2 and the nature of protein interactions mediating cell-cell recognition.
    Immunol Rev. 1998 Jun;163:217-36 PMID: 9700513
  14. The X-linked lymphoproliferative-disease gene product SAP regulates signals induced through the co-receptor SLAM.
    Nature. 1998 Oct 1;395(6701):462-9 PMID: 9774102
  15. Identification of the 2B4 molecule as a counter-receptor for CD48.
    J Immunol. 1998 Dec 1;161(11):5809-12 PMID: 9834056
  16. 2B4, the natural killer and T cell immunoglobulin superfamily surface protein, is a ligand for CD48.
    J Exp Med. 1998 Dec 7;188(11):2083-90 PMID: 9841922
  17. Molecular characterization of a novel human natural killer cell receptor homologous to mouse 2B4.
    Tissue Antigens. 1999 Jul;54(1):27-34 PMID: 10458320
Article Info
Journal
The Biochemical journal
Abbr.
Biochem J
ISSN
0264-6021
DOI
10.1042/0264-6021:3610431
Email
john.murphy@kcl.ac.uk
Published
2002-02-01
Pages
431-6
Language
English
Region
England
NLM ID
2984726R
PMCID
PMC1222324
Subset
IM
Databases
GENBANK
AJ276429
External Links
PubMed source DOI: 10.1042/0264-6021:3610431 PMC Full Text View journal details
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