Home LiteratureArticle Details

PMID: 11801174 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S.

Epigenetics as a first exit problem.

Physical review letters ·Vol. 88 ·No. 4 ·2002-01-28 ·Pages 048101

Aurell E, Sneppen K

Abstract

We develop a framework to discuss the stability of epigenetic states as first exit problems in dynamical systems with noise. We consider in particular the stability of the lysogenic state of the lambda prophage. The formalism defines a quantitative measure of robustness of inherited states.

MeSH Terms

Bacteriophage lambda/genetics,metabolism Binding Sites DNA, Viral/genetics,metabolism DNA-Binding Proteins/metabolism Escherichia coli/virology Gene Expression Regulation, Viral Lysogeny/genetics Models, Genetic Repressor Proteins/metabolism Viral Proteins/metabolism Viral Regulatory and Accessory Proteins

Chemicals

DNA, Viral DNA-Binding Proteins Repressor Proteins Viral Proteins Viral Regulatory and Accessory Proteins phage repressor proteins

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Aurell E

SICS, Box 1263, SE-164 29 Kista, Sweden.

Sneppen K

Article Info

Journal

Physical review letters

Abbr.

Phys Rev Lett

ISSN

0031-9007

DOI

10.1103/PhysRevLett.88.048101

Published

2002-01-28

Epub

2002-00-08

Pages

048101

Language

English

Region

United States

NLM ID

0401141

Subset

External Links

PubMed source DOI: 10.1103/PhysRevLett.88.048101 View journal details

Analysis Services

Epigenetics as a first exit problem.

Contact

WeChat Official Account