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PMID: 11792846 Published · ppublish English Journal Article Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S.

APH-1 is a multipass membrane protein essential for the Notch signaling pathway in Caenorhabditis elegans embryos.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 99 ·No. 2 ·2002-01-22 ·Pages 775-9

Goutte C, Tsunozaki M, Hale VA, Priess JR

Abstract

Early embryonic cells in Caenorhabditis elegans embryos interact through a signaling pathway closely related to the Notch signaling pathway in Drosophila and vertebrates. Components of this pathway include a ligand, receptor, the presenilin proteins, and a novel protein, APH-2, that is related to the Nicastrin protein in humans. Here we identify the aph-1 gene as a new component of the Notch pathway in Caenorhabditis elegans. aph-1 is predicted to encode a novel, highly conserved multipass membrane protein. We show that aph-1 and the presenilin genes share a similar function in that they are both required for proper cell-surface localization of APH-2/Nicastrin.

MeSH Terms
Amino Acid Sequence Amyloid Precursor Protein Secretases Animals Caenorhabditis elegans/embryology,genetics Caenorhabditis elegans Proteins/genetics,physiology Cell Membrane/physiology Genes, Helminth Helminth Proteins/genetics,physiology Homeodomain Proteins/genetics,physiology Membrane Glycoproteins/genetics,physiology Membrane Proteins/genetics,physiology Molecular Sequence Data Mutation Phenotype Receptors, Notch Sequence Homology, Amino Acid Signal Transduction
Chemicals
APH-1 protein, C elegans Caenorhabditis elegans Proteins Helminth Proteins Homeodomain Proteins Membrane Glycoproteins Membrane Proteins Receptors, Notch aph-2 protein, C elegans nicastrin protein Amyloid Precursor Protein Secretases
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Goutte Caroline
Department of Biology, Amherst College, Amherst, MA 01002, USA. cegoutte@amherst.edu
Tsunozaki Makoto
Hale Valerie A
Priess James R
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.022523499
Email
cegoutte@amherst.edu
Published
2002-01-22
Epub
2002-00-15
Pages
775-9
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC117381
Subset
IM
External Links
PubMed source DOI: 10.1073/pnas.022523499 PMC Full Text View journal details
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