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PMID: 11788827 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Identification of foreign gene sequences by transcript filtering against the human genome.

Nature genetics ·Vol. 30 ·No. 2 ·2002-02-00 ·Pages 141-2

Weber G, Shendure J, Tanenbaum DM, Church GM, Meyerson M

Abstract

We have developed a computational subtraction approach to detect microbial causes for putative infectious diseases by filtering a set of human tissue-derived sequences against the human genome. We demonstrate the potential of this method by identifying sequences from known pathogens in established expressed-sequence tag libraries.

MeSH Terms

DNA, Viral/genetics,isolation & purification Databases, Genetic Expressed Sequence Tags Gene Library Genetics, Microbial Genome, Human Genome, Viral Humans Sequence Analysis, DNA Viruses/genetics,pathogenicity

Chemicals

DNA, Viral

Authors & Affiliations

5 authors, click to expand affiliations / ORCID

Weber Griffin

Department of Adult Oncology, Dana-Farber Cancer Institute, 44 Binney Street, Boston, Massachusetts 02115, USA.

Shendure Jay

Tanenbaum David M

Church George M

Meyerson Matthew

Article Info

Journal

Nature genetics

Abbr.

Nat Genet

ISSN

1061-4036

DOI

10.1038/ng818

Published

2002-02-00

Epub

2002-00-14

Pages

141-2

Language

English

Region

United States

NLM ID

9216904

Subset

Corrections

CommentIn

PMID: 11818955

External Links

PubMed source DOI: 10.1038/ng818 View journal details

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Identification of foreign gene sequences by transcript filtering against the human genome.

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