Micro-RNAs: small is plentiful.
Two small temporally regulated RNAs (stRNAs)* of approximately 22 nucleotides regulate timing of gene expression during development of the nematode C. elegans. This regulation occurs at a posttranscriptional, presumably translational, level and is distinct from RNA interference (RNAi). One of the two stRNAs, let-7, as well as its target gene, lin-41, are highly conserved even in humans, suggesting a wide employment of stRNA-mediated gene regulation. Recent reports indicate that these two stRNAs are indeed likely to represent only the tip of an iceberg with hundreds or more of additional micro-RNAs (miRNAs) existing in metazoans. miRNAs might thus be previously underestimated key participants in the field of gene regulation.
27 references, click to expand
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Genes and mechanisms related to RNA interference regulate expression of the small temporal RNAs that control C. elegans developmental timing.Cell. 2001 Jul 13;106(1):23-34 PMID: 11461699
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Drosophila neuroblasts sequentially express transcription factors which specify the temporal identity of their neuronal progeny.Cell. 2001 Aug 24;106(4):511-21 PMID: 11525736
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The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14.Cell. 1993 Dec 3;75(5):843-54 PMID: 8252621
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